Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Immunos, Biopolis, Singapore.
Immunol Cell Biol. 2010 May-Jun;88(4):387-92. doi: 10.1038/icb.2010.38. Epub 2010 Mar 23.
Langerhans cells (LCs) refer to the dendritic cells (DCs) that populate the epidermis. Strategically located at one of the body's largest interfaces with the external environment, they form the first line of defense against pathogens that breach the skin. Although LCs share several phenotypical and functional features with lymphoid and non-lymphoid organ DCs, they also have unique properties that distinguish them from most DC populations. In this review, we will discuss the key mechanisms that regulate LC homeostasis in quiescent and inflamed skin. We will also discuss recent evidence that suggests that LCs arise from dedicated precursors during early embryonic development.
郎格汉斯细胞 (LCs) 是指分布在表皮中的树突状细胞 (DCs)。它们位于人体与外部环境最大的界面之一，是抵御突破皮肤的病原体的第一道防线。虽然 LCs 在表型和功能上与淋巴样和非淋巴样器官 DCs 有一些共同特征，但它们也有独特的特性，使其与大多数 DC 群体区分开来。在这篇综述中，我们将讨论调节静止和炎症皮肤中 LC 动态平衡的关键机制。我们还将讨论最近的证据表明，LCs 是在早期胚胎发育过程中由专门的前体产生的。
