Luce D, Leclerc A, Marne M J, Gerin M, Casal A, Brugere J
Unité 88 INSERM, Paris.
Rev Epidemiol Sante Publique. 1991;39(1):7-16.
A case-control study was conducted to examine occupational risk factors for sinonasal cancer. 207 cases and 409 controls (323 cancer hospital controls and 86 controls selected from lists provided by the cases) were included in the study. All cases and controls were interviewed by specially trained physicians. Detailed information on occupational history was collected, in addition to other potential risk factors for nasal cancer. Results are presented for two histologic types: adenocarcinoma and squamous cell carcinoma. Among males, the risk of adenocarcinoma was significantly elevated for carpenter and joiners (OR = 17.7) and other woodworkers (OR = 26.9). A significant increase in risk of squamous cell cancer (OR = 2.5) and a moderate increase in risk of adenocarcinoma (OR = 1.7; NS) were noted for construction workers. Among females, an excess risk of squamous cell carcinoma was associated with employment in textile industry (OR = 2.9). Elevated risks of squamous cell cancer were observed for farm workers of both sexes (males: OR = 2.2; females OR = 4.9).
开展了一项病例对照研究,以调查鼻窦癌的职业风险因素。该研究纳入了207例病例和409名对照(323名癌症医院对照和86名从病例提供的名单中选取的对照)。所有病例和对照均由经过专门培训的医生进行访谈。除了收集鼻癌的其他潜在风险因素外,还收集了详细的职业史信息。结果呈现了两种组织学类型:腺癌和鳞状细胞癌。在男性中,木匠和细木工(比值比=17.7)以及其他木工(比值比=26.9)患腺癌的风险显著升高。建筑工人患鳞状细胞癌的风险显著增加(比值比=2.5),患腺癌的风险中度增加(比值比=1.7;无显著性差异)。在女性中,纺织业就业与鳞状细胞癌的额外风险相关(比值比=2.9)。男女农场工人患鳞状细胞癌的风险均升高(男性:比值比=2.2;女性比值比=4.9)。