Parshikova S M, Khasanov Sh R
Vopr Onkol. 1991;37(3):283-8.
The value of morphologic features to be used prognosing dissemination and survival in skin malignant melanoma is discussed. Single-factor statistical analysis showed tumor thickness, extent of invasion or local spreading, clinico-morphologic pattern, lymphoid-plasmocytic infiltration, mitotic activity and cell composition to be the most reliable in predicting survival and dissemination in clinical stage I malignant melanoma of the skin. These parameters should be evaluated at microscopic evaluation of the tumor. Two-, five- and ten-year prognosis was obtained by multifactorial analysis yielding credibilities of 86.2, 78.5 and 71% for survival and 61.5, 68.7 and 74.3% for lethality, respectively.
讨论了用于预测皮肤恶性黑色素瘤扩散和生存情况的形态学特征的价值。单因素统计分析表明，肿瘤厚度、浸润范围或局部扩散、临床形态学模式、淋巴浆细胞浸润、有丝分裂活性和细胞组成在预测临床I期皮肤恶性黑色素瘤的生存和扩散方面最为可靠。这些参数应在肿瘤的显微镜评估中进行评估。通过多因素分析得出了2年、5年和10年的预后情况，生存率的可信度分别为86.2%、78.5%和71%，致死率的可信度分别为61.5%、68.7%和74.3%。
