Kullendorff C M, Arnbjörnsson E, Wiebe T
Department of Pediatric Surgery, University Hospital, Lund, Sweden.
Eur J Pediatr Surg. 1991 Feb;1(1):21-3. doi: 10.1055/s-2008-1042452.
25 children (18 boys and 7 girls) were treated for non-Hodgkin's lymphomas (NHL) during 1982-1990. The age at diagnosis was 2-15 years. Five of the 25 children died. Of the 25 children 6 patients had the diagnosis of intraabdominal NHL. The presenting abdominal symptoms for these 6 patients were abdominal pain in 4 cases, nausea 3, abdominal distention 2, icterus 1 and diarrhoea 1. Four of the 6 patients with abdominal NHL underwent laparotomy but the diagnosis was unknown before surgery. The indication for explorative laparotomy was in all cases a tumor of unknown etiology combined with ascites in 2 cases and icterus in 1 case. At surgery there was a tumor localized around the porta hepatitis in 1 case and in the right ovarium in 1 case. Furthermore, spread infiltrative growth of tumor was found in 3 cases, with infiltration of the peritoneum in 2 of these cases. A specimen for peroperative histological examination was taken and gave the conclusive diagnosis of NHL in 4 of 6 cases. Staging laparotomy, palliative tumor resection and radical surgery are preferably avoided. For proper treatment an adequate biopsy is important. The management of children with NHL is a multidisciplinary approach.
1982年至1990年间，对25名儿童（18名男孩和7名女孩）进行了非霍奇金淋巴瘤（NHL）治疗。诊断时年龄为2至15岁。25名儿童中有5名死亡。25名儿童中，6例被诊断为腹内NHL。这6例患者出现的腹部症状为：4例腹痛、3例恶心、2例腹胀、1例黄疸和1例腹泻。6例腹内NHL患者中有4例行剖腹手术，但术前诊断不明。所有病例中剖腹探查的指征均为病因不明的肿瘤，其中2例伴有腹水，1例伴有黄疸。手术时，1例肿瘤位于肝门周围，1例位于右侧卵巢。此外，3例发现肿瘤呈弥漫性浸润性生长，其中2例浸润至腹膜。6例中有4例获取了手术中组织学检查标本，确诊为NHL。分期剖腹手术、姑息性肿瘤切除和根治性手术最好避免。为进行恰当治疗，充分活检很重要。儿童NHL的治疗需多学科方法。
