Goto S, Grosfeld J L
Department of Surgery, Indiana University School of Medicine, Indianapolis 46202.
Eur J Pediatr Surg. 1991 Feb;1(1):24-6. doi: 10.1055/s-2008-1042453.
Ileo- or jejuno-endorectal pull-through following total colectomy (TC) and massive small bowel resection (SBR) was performed in the rat to investigate the natural course of its condition. Animals were assigned to five experimental groups: TC only (n = 6), TC + 25% SBR (n = 6), TC + 50% SBR (n = 6), TC + 75% SBR (n = 6), and sham operation (SH) (n = 6). Survival at 28 days was 100% in groups TC and SH, while all rats receiving both TC and massive SBR eventually died within 14 days. Their number of survival days were 10.5 +/- 0.76 in group TC + 25% SBR*, 9.5 +/- 0.56 in group TC + 50% SBR*, and 5.8 +/- 0.48 in group TC + 75% SBR (*p less than 0.001 vs. group TC + 75% SBR). Changes in % of initial body weight revealed that the rats who received both TC and massive SBR showed a tremendous decrease of weight in the ensuing postoperative days and its degree was attributable to the extent of SBR. Our data support the clinical trials to preserve the aganglionic terminal ileum for the surgical treatment of extensive aganglionosis.
在大鼠中进行全结肠切除术（TC）和大量小肠切除术（SBR）后行回肠或空肠直肠内拖出术，以研究其病情的自然发展过程。将动物分为五个实验组：仅行TC（n = 6）、TC + 25% SBR（n = 6）、TC + 50% SBR（n = 6）、TC + 75% SBR（n = 6）和假手术（SH）（n = 6）。TC组和SH组28天的存活率为100%，而所有接受TC和大量SBR的大鼠最终均在14天内死亡。在TC + 25% SBR组，其存活天数为10.5±0.76*，在TC + 50% SBR组为9.5±0.56*，在TC + 75% SBR组为5.8±0.48（*与TC + 75% SBR组相比，p＜0.001）。初始体重百分比的变化显示，接受TC和大量SBR的大鼠在术后随后的日子里体重显著下降，其下降程度与SBR的范围有关。我们的数据支持在广泛神经节缺失症的手术治疗中保留无神经节终末回肠的临床试验。
