LaMancusa J, Cooper R, Vieth R, Wright F
Department of Neurology, Ohio State University, Columbus 43210.
Clin Electroencephalogr. 1991 Apr;22(2):112-7. doi: 10.1177/155005949102200212.
In a retrospective study at a large children's hospital, we identified 92 children who had received barbiturates that were simultaneously discontinued at the time they were being evaluated for brain death in the presence of electrocerebral silence and clinical brain death by physical exam. Of these 92 children, 67 had barbiturate levels that were monitored from initial therapeutic or subtherapeutic levels. Repeat EEGs were obtained in 76 patients, and in all electrocerebral silence and clinical brain death (by exam) persisted despite the lower barbiturate levels. The study suggests that therapeutic and subtherapeutic barbiturate levels have no effect on the outcome of children who fulfill the criteria for brain death.
在一家大型儿童医院进行的一项回顾性研究中，我们确定了92名接受过巴比妥类药物治疗的儿童，这些儿童在因脑电静息和体格检查判定为临床脑死亡而接受脑死亡评估时，同时停用了巴比妥类药物。在这92名儿童中，67名儿童的巴比妥类药物水平从初始治疗水平或亚治疗水平开始进行监测。76名患者进行了重复脑电图检查，尽管巴比妥类药物水平降低，但所有患者的脑电静息和临床脑死亡（通过检查判定）仍然持续存在。该研究表明，治疗水平和亚治疗水平的巴比妥类药物对符合脑死亡标准的儿童的预后没有影响。
