Hennighausen G, Tiefenbach B
Arch Exp Veterinarmed. 1977;31(4):527-32.
Chlorocholine chloride (CCC) inhibits neuromuscular transduction of excitation and, consequently, leads to respiratory arrest in cases of acute intoxication. An account is given of the relationships between neuromuscularly blocking activity and acute toxicity of CCC. Several animal species and pharmacological models are used to produce evidence to the effect that CCC-caused inhibition of neuromuscular transmission of excitation is characterised by parameters typical of block due to depolarisation. The differentiated sensitivity of species to depolarising neuromuscular blockers is thought to be the decisive cause of species differences regarding acute toxicity of CCC. Conclusions are discussed which may be derived from the above findings regarding acute CCC toxicity to man and agricultural animal.
氯化氯胆碱（CCC）抑制神经肌肉兴奋传递，因此在急性中毒情况下会导致呼吸骤停。文中阐述了CCC的神经肌肉阻滞活性与急性毒性之间的关系。使用了几种动物物种和药理学模型来证明，CCC引起的神经肌肉兴奋传递抑制具有去极化所致阻滞的典型特征参数。物种对去极化神经肌肉阻滞剂的差异敏感性被认为是CCC急性毒性存在物种差异的决定性原因。文中讨论了从上述关于CCC对人类和家畜急性毒性的研究结果中可能得出的结论。
