Pronzato P, Queirolo P, Vidili M G, Amoroso D, Bertelli G, Sertoli M R, Rosso R
Istituo Nazionale per la Ricerca sul Cancro, Genova, Italia.
Chemotherapy. 1991;37(2):146-9. doi: 10.1159/000238847.
In 19 patients with advanced pretreated breast cancer, vinblastine was administered by continuous venous infusion (2 mg/m2/24 h for 120 h every 3 weeks), using a totally implanted venous access and a portable pump. A total of 55 courses were given. Five objective responses were observed. Drug-related toxicity consisted mainly of leukopenia (4 patients), fever (4 patients) and nausea and vomiting (3 patients). Catheter-related toxicity was observed in 4 patients (21%) and consisted of infection of the skin pocket in 1 patient and dislodging of the needle with drug extravasation in 3 patients.
