Mazzocchi G, Neri G, Belloni A S, Robba C, Nussdorfer G G
Beitr Pathol. 1977 Nov;161(3):221-9. doi: 10.1016/s0005-8165(77)80078-4.
The effects of dexamethasone on the half-life of rat adrenocortical mitochondria were investigated by high resolution autoradiography and liquid scintillation spectroscopy. According to the method employed, the half-life averaged 11.27 and 10.46 days. Dexamethasone was found to decrease significantly this parameter (to about 5 days). Since dexamethasone-treated rats can be regarded as pharmacologically hypophysectomized animals, the data indicates that ACTH is involved in the maintenance of the half-life of adrenocortical mitochondria.
