Emami B, Lyman J, Brown A, Coia L, Goitein M, Munzenrider J E, Shank B, Solin L J, Wesson M
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110.
Int J Radiat Oncol Biol Phys. 1991 May 15;21(1):109-22. doi: 10.1016/0360-3016(91)90171-y.
The importance of knowledge on tolerance of normal tissue organs to irradiation by radiation oncologists cannot be overemphasized. Unfortunately, current knowledge is less than adequate. With the increasing use of 3-D treatment planning and dose delivery, this issue, particularly volumetric information, will become even more critical. As a part of the NCI contract N01 CM-47316, a task force, chaired by the primary author, was formed and an extensive literature search was carried out to address this issue. In this issue. In this manuscript we present the updated information on tolerance of normal tissues of concern in the protocols of this contract, based on available data, with a special emphasis on partial volume effects. Due to a lack of precise and comprehensive data base, opinions and experience of the clinicians from four universities involved in the contract have also been contributory. Obviously, this is not and cannot be a comprehensive work, which is beyond the scope of this contract.
放射肿瘤学家了解正常组织器官对辐射的耐受性这一知识的重要性，无论如何强调都不为过。不幸的是，目前的知识还不够充分。随着三维治疗计划和剂量输送的日益广泛应用，这个问题，尤其是容积信息，将变得更加关键。作为美国国立癌症研究所（NCI）合同N01 CM - 47316的一部分，由第一作者担任主席的一个特别工作组成立了，并进行了广泛的文献检索以解决这个问题。在本论文中，我们根据现有数据，介绍了该合同方案中所关注的正常组织耐受性的最新信息，特别强调了部分容积效应。由于缺乏精确和全面的数据库，参与该合同的四所大学的临床医生的意见和经验也起到了一定作用。显然，这不是也不可能是一项全面的工作，这超出了本合同的范围。
