Shank B, LoSasso T, Brewster L, Burman C, Cheng E, Chu J C, Drzymala R E, Manolis J, Pilepich M V, Solin L J
Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
Int J Radiat Oncol Biol Phys. 1991 May 15;21(1):253-65. doi: 10.1016/0360-3016(91)90183-5.
The role of three-dimensional (3-D) treatment planning for postoperative radiation therapy was evaluated for rectal carcinoma as part of an NCI contract awarded to four institutions. It was found that the most important contribution of 3-D planning for this site was the ability to plan and localize target and normal tissues at all levels of the treatment volume, rather than using the traditional method of planning with only a single central transverse slice and simulation films. There was also a slight additional improvement when there were no constraints on the types of plans (i.e., when noncoplanar beams were used). Inhomogeneity considerations were not important at this site under the conditions of planning, i.e., with energies greater than 4 MV and multiple fields. Higher beam energies (15-25 MV) were preferred by a small margin over lower energies (down to 4 MV). The beam's eye view and dose-volume histograms were found quite useful as planning tools, but it was clear that work should continue on better 3-D displays and improved means of translating such plans to the treatment area.
作为授予四个机构的美国国立癌症研究所合同的一部分，对直肠癌术后放射治疗的三维（3-D）治疗计划的作用进行了评估。结果发现，该部位三维计划最重要的贡献在于能够在治疗体积的各个层面规划和定位靶区及正常组织，而不是采用仅使用单个中央横向切片和模拟胶片的传统规划方法。当对计划类型没有限制时（即使用非共面射束时），也有轻微的额外改善。在规划条件下，即在能量大于4兆伏且采用多个射野时，该部位的不均匀性考虑并不重要。较高的射束能量（15 - 25兆伏）略优于较低能量（低至4兆伏）。射束视角和剂量体积直方图被发现作为规划工具非常有用，但很明显，应继续致力于更好的三维显示以及将此类计划转化至治疗区域的改进方法。
