Masterson M E, Barest G, Chui C S, Doppke K P, Epperson R D, Harms W B, Krippner K E, Mohan R, Slessinger E D, Sontag M R
Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
Int J Radiat Oncol Biol Phys. 1991 May 15;21(1):37-58. doi: 10.1016/0360-3016(91)90166-2.
Under the auspices of NCI contracts, four institutions have collaborated to assess the accuracy of the pixel-based dose calculation methods they employ for external photon treatment planning. The approach relied on comparing calculations using each group's algorithm with measurements in phantoms of increasing complexity. The first set of measurements consisted of ionization chamber measurements in water phantoms in normally incident square fields, an elongated field, a wedged field, a blocked field, and an obliquely incident beam. The second group of measurements was carried out using thermoluminescent dosimeters in phantoms designed to investigate the effects of surface curvature, high density heterogeneities, and low density heterogeneities. The final study tested the entire treatment planning system, including CT data conversion, in an anthropomorphic phantom. Overall, good agreement between calculation and measurements was found for all algorithms. Regions in which discrepancies were observed are pointed out, areas for algorithm improvement are identified and the clinical import of algorithm accuracy is discussed.
在美国国立癌症研究所（NCI）合同的支持下，四家机构合作评估了它们用于外照射光子治疗计划的基于像素的剂量计算方法的准确性。该方法依赖于将每组算法的计算结果与在复杂度不断增加的体模中的测量结果进行比较。第一组测量包括在正常入射方野、细长野、楔形野、遮挡野和斜入射束的水模中进行电离室测量。第二组测量是在旨在研究表面曲率、高密度不均匀性和低密度不均匀性影响的体模中使用热释光剂量计进行的。最后一项研究在一个仿真人体体模中测试了整个治疗计划系统，包括CT数据转换。总体而言，所有算法的计算结果与测量结果之间都有良好的一致性。指出了观察到差异的区域，确定了算法改进的领域，并讨论了算法准确性的临床意义。
