Kargin Ramazan, Esen Ozlem, Akçakoyun Mustafa, Pala Selçuk, Candan Ozkan, Omaygenç Mehmet Onur, Dogan Cem, Barutçu Irfan, Esen Ali Metin, Ozdemir Nihal
Kartal Kofluyolu Yüksek Ihtisas Education and Research Hospital, Istanbul, Turkey.
J Heart Valve Dis. 2010 Jan;19(1):35-42.
The Tei index, obtained from tissue Doppler echocardiography (TDE-Tei index), has emerged as a new parameter that incorporates both systolic and diastolic time intervals to express global ventricular performance. The study aim was to evaluate whether the TDE-Tei index also correlates with left ventricular (LV) systolic and diastolic function and plasma brain natriuretic peptide (BNP) levels and echocardiographic parameters in patients with symptoms of mitral regurgitation (MR).
Thirty-three patients (17 males, 16 females; mean age 57 +/- 17 years) with isolated organic MR underwent transthoracic echocardiography and tissue Doppler echocardiography, and were also assessed for symptoms. Plasma BNP levels were also monitored. The patients were allocated to two groups, based on a TDE-Tei index cut-off level of 0.51.
Correlations were identified between the TDE-Tei index and LV ejection fraction (LVEF) (r = -0.54), plasma BNP level (r = 0.5), MR index (r = 0.48), MR jet area (r = 0.38), MR effective regurgitant orifice area (r = 0.37), LV end-systolic diameter (r = 0.43), E/Ea (r = 0.41) and NYHA functional class (r = 0.38). However, no correlations were identified with the left atrial area, MR vena contracta width, MR regurgitant volume, MR regurgitant fraction, systolic pulmonary artery pressure, LV end-diastolic dimensions and LV diastolic dysfunction. The mean values of the TDE-Tei index were 0.40 +/- 11, 0.44 +/- 11 and 0.53 +/- 16 in MR patients in NYHA classes I, II and III, respectively.
In patients with isolated organic MR, the TDE Tei index was found to correlate well with LVEF and plasma BNP levels, and thus may be considered as a new echocardiographic parameter for the assessment of global ventricular function during patient follow up.
组织多普勒超声心动图获得的Tei指数（TDE - Tei指数）已成为一个新参数，它整合了收缩期和舒张期时间间期来表达整体心室功能。本研究目的是评估TDE - Tei指数是否也与二尖瓣反流（MR）症状患者的左心室（LV）收缩和舒张功能、血浆脑钠肽（BNP）水平及超声心动图参数相关。
33例孤立性器质性MR患者（17例男性，16例女性；平均年龄57±17岁）接受经胸超声心动图和组织多普勒超声心动图检查，并评估症状。同时监测血浆BNP水平。根据TDE - Tei指数截断值0.51将患者分为两组。
发现TDE - Tei指数与左心室射血分数（LVEF）（r = -0.54）、血浆BNP水平（r = 0.5）、MR指数（r = 0.48）、MR射流面积（r = 0.38）、MR有效反流口面积（r = 0.37）、左心室收缩末期直径（r = 0.43）、E/Ea（r = 0.41）和纽约心脏协会（NYHA）功能分级（r = 0.38）相关。然而，未发现与左心房面积、MR反流束宽度、MR反流容积、MR反流分数、收缩期肺动脉压、左心室舒张末期内径及左心室舒张功能障碍相关。NYHA I级、II级和III级MR患者的TDE - Tei指数平均值分别为0.40±11、0.44±11和0.53±16。
在孤立性器质性MR患者中，发现TDE Tei指数与LVEF和血浆BNP水平密切相关，因此可被视为患者随访期间评估整体心室功能的一个新的超声心动图参数。
