靶细胞上雌激素受体的存在及磷酸雌莫司汀的抗增殖活性：体外人肿瘤的正相关关系
Presence of oestrogen receptors on target cells and antiproliferative activity of estramustine phosphate: positive correlation for human tumours in vitro.
作者信息
Pavelić J, Zgradić I, Pavelić K
机构信息
Ruter Bosković Institute, Zagreb, Yugoslavia.
出版信息
J Cancer Res Clin Oncol. 1991;117(3):244-8. doi: 10.1007/BF01625432.
Abstract
Incubation with estramustine phosphate for 24 h inhibited DNA, RNA and protein synthesis in primary cultures of human kidney, mammary, prostatic, cervical and endometrial carcinoma. Not only the presence, but also the concentration of oestrogen receptors correlated with estramustine phosphate effects on tumour cell proliferation.
摘要
用磷酸雌莫司汀孵育24小时可抑制人肾癌、乳腺癌、前列腺癌、宫颈癌和子宫内膜癌原代培养物中的DNA、RNA和蛋白质合成。雌激素受体的存在及浓度均与磷酸雌莫司汀对肿瘤细胞增殖的作用相关。
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