Center of Microbial Pathogenesis, Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.
Mol Oral Microbiol. 2010 Feb;25(1):15-24. doi: 10.1111/j.2041-1014.2009.00564.x.
Streptococcus pneumoniae colonization of the human airway is an essential precursor for disease; however, the mechanisms by which the bacterium establishes and maintains colonization are poorly understood. It is becoming increasingly clear that S. pneumoniae expresses glycosidases that can modify many glycan structures present in the human airway, including N-linked glycans, O-linked glycans, and glycosaminoglycans. Many of these glycosidases have been shown to contribute to in vivo colonization. Although the precise role of these glycosidases during colonization remains to be elucidated, in vitro assays suggest that pneumococcal modification of host sugars may contribute to colonization in a variety of ways. Experimental evidence supports a role for pneumococcal glycosidases in providing a carbon source for growth, biofilm formation, competition with other bacteria within the airway, and exposing receptors for adherence. Herein we review the ability of S. pneumoniae to modify host sugars and the functional effects of these modifications.
肺炎链球菌在人体气道中的定植是疾病发生的重要前提；然而，细菌建立和维持定植的机制还不太清楚。越来越明显的是，肺炎链球菌表达的糖苷酶可以修饰人体气道中存在的许多聚糖结构，包括 N-连接聚糖、O-连接聚糖和糖胺聚糖。许多这些糖苷酶已被证明有助于体内定植。尽管这些糖苷酶在定植过程中的具体作用仍有待阐明，但体外实验表明，肺炎链球菌对宿主糖的修饰可能以多种方式促进定植。实验证据支持肺炎链球菌糖苷酶在提供生长碳源、生物膜形成、与气道内其他细菌竞争以及暴露粘附受体方面的作用。本文综述了肺炎链球菌修饰宿主糖的能力以及这些修饰的功能影响。
