Torres O A, Calzada J E, Beraún Y, Morillo C A, González A, González C I, Martín J
Instituto de Parasitología y Biomedicina López-Neyra, CSIC, Granada, Spain.
Tissue Antigens. 2010 Aug;76(2):131-4. doi: 10.1111/j.1399-0039.2010.01478.x. Epub 2010 Mar 22.
The aim of this study was to investigate the role of the IL-6-174G/C gene polymorphism in susceptibility/resistance to Trypanosoma cruzi infection in two independent cohorts from Colombia and Peru. We determined the IL-6-174G/C genotypes in a sample of 399 seronegative individuals and 317 serologically positive patients from Colombia and Peru. All individuals are from regions where T. cruzi infection is endemic. No statistically significant differences in the frequency of IL-6-174G/C gene polymorphism between chagasic patients and controls or between asymptomatic and individuals with cardiomyopathy were observed. Our results do not support an evidence for a major role contribution of this IL-6 gene polymorphism in the susceptibility to or clinical manifestations of Chagas disease in these studied cohorts.
本研究的目的是调查IL-6 -174G/C基因多态性在来自哥伦比亚和秘鲁的两个独立队列中对克氏锥虫感染易感性/抵抗力的作用。我们在来自哥伦比亚和秘鲁的399名血清阴性个体和317名血清学阳性患者的样本中确定了IL-6 -174G/C基因型。所有个体均来自克氏锥虫感染流行地区。在恰加斯病患者与对照组之间或无症状个体与患有心肌病的个体之间，未观察到IL-6 -174G/C基因多态性频率有统计学上的显著差异。我们的结果不支持该IL-6基因多态性在这些研究队列中对恰加斯病易感性或临床表现起主要作用的证据。
