McLeod Family Medicine Center, Florence, SC 29506, USA.
Ann Pharmacother. 2010 Apr;44(4):737-9. doi: 10.1345/aph.1M614.
The passionate topic in pharmacotherapy belongs to medication safety. A basic premise in medicine is to first do no harm: primum non nocere. But can this ancient principle hold true concerning medications? Medication alerts from the Food and Drug Administration (FDA) are being transmitted through emails daily. Recently, an FDA advisory committee reviewed acetaminophen and the risk of acute liver injury. They made recommendations that could change the patient utilization and market dynamics of acetaminophen. This article is a reminder that safety is always at risk when progress and benefit are the outcomes of pharmacotherapy. Risk and benefit are mutually inclusive ideas and should never be separated. When risk dominates, fear is generated.
药物治疗学中一个热门的话题是用药安全。医学的一个基本前提是首先不造成伤害：首要原则是不伤害。但是这个古老的原则在药物方面还适用吗？食品药品监督管理局（FDA）每天都会通过电子邮件发出用药警报。最近，FDA 顾问委员会审查了对乙酰氨基酚和急性肝损伤的风险。他们提出的建议可能会改变对乙酰氨基酚的患者使用和市场动态。这篇文章提醒我们，当药物治疗的结果是进步和受益时，安全总是存在风险。风险和收益是相互包含的概念，永远不应分开。当风险占主导地位时，就会产生恐惧。
