TLR4 和 NOD2/CARD15 基因多态性及其在胃癌发生中的可能作用。
TLR4 and NOD2/CARD15 genetic polymorphisms and their possible role in gastric carcinogenesis.
机构信息
Department of Pediatrics, Messina University, Italy
出版信息
Anticancer Res. 2010 Feb;30(2):513-7.
UNLABELLED
The aim of this study was to evaluate the role of TLR4 and NOD2/CARD15 genes in gastric carcinogenesis.
PATIENTS AND METHODS
We investigated the allelic frequencies of TLR4 (D299G and T399I) and NOD2/CARD15 (R702W, G908R, and L1007finsC) SNPs in 87 asymptomatic serologically H. pylori-positive individuals (Group I), in 63 patients with antrum-predominant gastritis (Group II) and in 60 patients with corpus-predominant gastritis or pangastritis (Group III).
RESULTS
There was significant difference in allelic frequencies of TLR4 D299G SNP in Group II (p=0.02; OR 2.97) as well as in Group III (p=0.001; OR 4.80). Significant difference of T399I SNP allele frequency was only found in Group III (p=0.009; OR 3.73). The allele frequencies of NOD2/CARD15 G908R and of L1007insC SNP were higher in Group III (p=0.003, OR 5.18; p=0.03; OR 3.66, respectively).
CONCLUSION
TLR4 and NOD2/CARD15 genes are associated with high risk Group III patients and, therefore, they appear to play a role in gastric carcinogenesis.
目的
本研究旨在评估 TLR4 和 NOD2/CARD15 基因在胃癌发生中的作用。
患者与方法
我们研究了 TLR4（D299G 和 T399I）和 NOD2/CARD15（R702W、G908R 和 L1007finsC）SNP 在 87 例无症状血清 H. pylori 阳性个体（I 组）、63 例胃窦炎患者（II 组）和 60 例胃体炎或全胃炎患者（III 组）中的等位基因频率。
结果
在 II 组（p=0.02；OR 2.97）和 III 组（p=0.001；OR 4.80）中，TLR4 D299G SNP 的等位基因频率存在显著差异。仅在 III 组中发现 T399I SNP 等位基因频率存在显著差异（p=0.009；OR 3.73）。NOD2/CARD15 G908R 和 L1007insC SNP 的等位基因频率在 III 组中较高（p=0.003，OR 5.18；p=0.03；OR 3.66）。
结论
TLR4 和 NOD2/CARD15 基因与高危 III 组患者相关，因此它们似乎在胃癌发生中发挥作用。
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