拉丁美洲肝细胞癌的病因：一项前瞻性、多中心、国际研究。

Etiology of hepatocellular carcinoma in Latin America: a prospective, multicenter, international study.

机构信息

Hospital Nacional Prof. A. Posadas, Buenos Aires, Argentina.

出版信息

Ann Hepatol. 2010 Jan-Mar;9(1):63-9.

PMID:20332549

Abstract

BACKGROUND/AIMS: No prospective study has been published investigating etiology of HCC in Latin America. The primary aim of this prospective study was to analyze the etiology of liver disease in patients with HCC from our area. Secondary aims were to evaluate staging using Okuda and BCLC classifications; and percentage of patients receiving treatment.

METHODS

The Governing Board of the Latin American Association for the Study of the Liver designed the protocol. During a 18 month period, all members were invited to load their incident HCC cases on line.

RESULTS

240 cases from 9 countries were uploaded, 174 were male (72.5%), median age was 64 years, interquartile range 57-72. In 85.4% of cases, patients had underlying cirrhosis. Main etiological factors were: HCV in 74 patients (30.8%), alcohol in 49 (20.4%), cryptogenic cirrhosis in 35 (14.6%), HBV in 26 (10.8%), HCV plus alcohol in 14 (5.8%). Considering the combinations, hepatitis C was shown in 91 patients (38%); chronic alcoholism in 68 patients (28%); and hepatitis B in 33 patients (14%). There were no significant differences between the groups in the age at diagnosis. Percentage of male gender was higher in groups of alcohol (94%), HCV plus alcohol (93%) and HBV (85%) than in cryptogenic cirrhosis (60%) and HCV (59%) (p<0.001).

CONCLUSIONS

Our prospective study showed that hepatitis C is the more frequent etiology of HCC in Latin America, followed by alcoholic cirrhosis. Demographical results showed a male predominance (male:female ratio 2.6) with an important proportion of patients being diagnosed at their sixties.

摘要

背景/目的：尚无前瞻性研究报道拉丁美洲 HCC 的病因。本前瞻性研究的主要目的是分析本地区 HCC 患者肝病的病因。次要目的是评估 Okuda 和 BCLC 分类的分期；以及接受治疗的患者比例。

方法

拉丁美洲肝病学会理事会设计了方案。在 18 个月的时间内，邀请所有成员在线加载他们的 HCC 病例。

结果

9 个国家的 240 例病例被上传，174 例为男性（72.5%），中位年龄为 64 岁，四分位间距为 57-72。85.4%的患者有基础肝硬化。主要病因因素为：HCV 感染 74 例（30.8%）、酒精 49 例（20.4%）、隐源性肝硬化 35 例（14.6%）、HBV 感染 26 例（10.8%）、HCV 加酒精 14 例（5.8%）。考虑到组合，乙型肝炎 C 显示在 91 例患者（38%）；慢性酒精中毒 68 例（28%）；乙型肝炎 33 例（14%）。各组之间的诊断年龄无显著差异。在酒精（94%）、HCV 加酒精（93%）和 HBV（85%）组中，男性比例高于隐源性肝硬化（60%）和 HCV（59%）（p<0.001）。