Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.
Dement Geriatr Cogn Disord. 2010;29(3):198-203. doi: 10.1159/000278348. Epub 2010 Mar 20.
To determine the factors associated with receiving specific treatment (cholinesterase inhibitors or/and memantine) for Alzheimer disease (AD) in elderly patients.
An observational study carried out in 289 consecutive outpatients aged >64 years with dementia. We collected data on specific AD therapy, sociodemographic variables, Barthel Index (BI), Lawton and Brody Index (LI), Mini Mental State Examination, Global Deterioration Scale (GDS), Charlson Index and the total number of drugs chronically prescribed. Patients receiving specific therapy for dementia were compared with the rest.
Two hundred and thirty-three (80.6%) patients were receiving specific treatment for dementia, with 197 (84.5%) receiving monotherapy and the rest (15.4%) combined therapy. The bivariate analysis showed that age, marital status, place of residence, BI and LI, cognitive status and disease severity (GDS) were factors associated with receiving specific dementia therapy. Multiple stepwise logistic regression analysis showed that a lower BI (beta = -0.25; odds ratio 0.976, 95% confidence interval = 0.966-0.986; p < 0.0001) was the only factor independently associated with not receiving specific therapy for AD.
Of the possible factors related to elderly patients receiving specific therapy for AD, a poor BI score was the most important factor associated with not receiving treatment.
确定与老年痴呆症（AD）患者接受特定治疗（胆碱酯酶抑制剂和/或美金刚）相关的因素。
对 289 名连续就诊的 64 岁以上痴呆症患者进行了一项观察性研究。我们收集了特定 AD 治疗、社会人口统计学变量、巴氏指数（BI）、劳顿和布罗迪指数（LI）、简易精神状态检查、总体衰退量表（GDS）、Charlson 指数和慢性处方药物总数的数据。将接受特定痴呆症治疗的患者与其余患者进行比较。
233 名（80.6%）患者接受了特定的痴呆症治疗，其中 197 名（84.5%）接受了单药治疗，其余（15.4%）接受了联合治疗。单变量分析表明，年龄、婚姻状况、居住地、BI 和 LI、认知状态和疾病严重程度（GDS）是与接受特定痴呆症治疗相关的因素。多步逻辑回归分析显示，BI 较低（β=-0.25；优势比 0.976，95%置信区间=0.966-0.986；p<0.0001）是与未接受 AD 特定治疗相关的唯一独立因素。
在与老年 AD 患者接受特定治疗相关的可能因素中，BI 评分较低是与未接受治疗最相关的因素。
