雌激素对慢性束缚应激诱导的抑郁样行为的预防作用。
Preventive effect of estrogen on depression-like behavior induced by chronic restraint stress.
机构信息
Institute of Brain and Behavior Science, College of Life Science, Shaanxi Normal University, Xi'an 710062, China.
出版信息
Neurosci Bull. 2010 Apr;26(2):140-6. doi: 10.1007/s12264-010-0609-9.
Abstract
OBJECTIVE
To investigate the roles of estrogen and kalirin-7 in chronic restraint stress (CRS)-induced depression and the pathophysiological mechanism of depression.
METHODS
Healthy female mice from Institute of Cancer Research (ICR) were randomly divided into 3 groups: control group, CRS group, and estrogen + CRS group. CRS was used to establish the animal model of depression. Forced swimming test and immunohistochemistry method were utilized to investigate the animal behavior and kalirin-7 expression in the hippocampus, respectively.
RESULTS
Compared with the control group, the CRS mice displayed depression-like behaviors, including a significant reduction in body weight, a significant increase in immobility time in forced swimming test, and a dramatic decrease in kalirin-7 expression in the hippocampus. However, administration of estrogen attenuated the CRS-induced negative behaviors, and simultaneously increased kalirin-7 expression.
CONCLUSION
Estrogen replacement therapy (ERT) could prevent CRS-induced depression-like behaviors in female ICR mice. Besides, kalirin-7 also plays a role in preventing CRS-induced depression-like behaviors.
摘要
目的
探讨雌激素和 kalirin-7 在慢性束缚应激（CRS）诱导的抑郁中的作用及抑郁的病理生理机制。
方法
来自癌症研究所（ICR）的健康雌性小鼠被随机分为 3 组：对照组、CRS 组和雌激素+CRS 组。CRS 用于建立抑郁动物模型。利用强迫游泳试验和免疫组织化学方法分别研究动物行为和海马中的 kalirin-7 表达。
结果
与对照组相比，CRS 小鼠表现出抑郁样行为，包括体重明显减轻、强迫游泳试验中不动时间明显增加以及海马 kalirin-7 表达显著降低。然而，雌激素给药可减轻 CRS 引起的负面行为，同时增加 kalirin-7 的表达。
结论
雌激素替代疗法（ERT）可预防雌性 ICR 小鼠的 CRS 诱导的抑郁样行为。此外，kalirin-7 也在预防 CRS 诱导的抑郁样行为中发挥作用。
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