一种与痘苗病毒14K“融合”蛋白具有同源性的羊口疮病毒序列。

An orf virus sequence showing homology to the 14K 'fusion' protein of vaccinia virus.

作者信息

Naase M, Nicholson B H, Fraser K M, Mercer A A, Robinson A J

机构信息

Department of Biochemistry and Physiology, University of Reading, Berkshire, U.K.

出版信息

J Gen Virol. 1991 May;72 ( Pt 5):1177-81. doi: 10.1099/0022-1317-72-5-1177.

DOI:10.1099/0022-1317-72-5-1177

PMID:2033392

Abstract

The nucleotide sequence of a region of DNA 30 kb from the right end of the orf virus genome has been determined. Examination of the sequences revealed an open reading frame encoding a 10K peptide with significant amino acid homology to the 14K 'fusion' protein reported in vaccinia virus. The orf virus sequence has a 31% identity with the vaccinia virus protein, but a higher level of homology of core predicted residues. The secondary structure of both proteins is also similar. The occurrence of the TAAAT sequence upstream from the initiation codon indicates that the sequence is likely to be transcribed late in infection.

摘要

已确定痘苗病毒基因组右端30 kb处一段DNA区域的核苷酸序列。对这些序列的检查揭示了一个开放阅读框，该阅读框编码一种10K肽，与痘苗病毒中报道的14K“融合”蛋白具有显著的氨基酸同源性。痘苗病毒序列与痘苗病毒蛋白的同一性为31%，但核心预测残基的同源性更高。这两种蛋白质的二级结构也相似。起始密码子上游TAAAT序列的出现表明该序列可能在感染后期转录。