• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Heat shock protein 70 (hsp70) as an emerging drug target.

作者信息

Evans Christopher G, Chang Lyra, Gestwicki Jason E

机构信息

Department of Pathology and the Life Sciences Institute, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, Michigan 48109-2216, USA.

出版信息

J Med Chem. 2010 Jun 24;53(12):4585-602. doi: 10.1021/jm100054f.

DOI:10.1021/jm100054f
PMID:20334364
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2895966/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78d9/2895966/c66403ea3788/nihms191232f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78d9/2895966/5bdc6fcefdd9/nihms191232f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78d9/2895966/06d7df31afda/nihms191232f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78d9/2895966/b9293faa5498/nihms191232f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78d9/2895966/25b8c92de3d3/nihms191232f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78d9/2895966/4b2b79e74a7b/nihms191232f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78d9/2895966/dd2657e031a2/nihms191232f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78d9/2895966/4f1fdc7a5632/nihms191232f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78d9/2895966/c66403ea3788/nihms191232f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78d9/2895966/5bdc6fcefdd9/nihms191232f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78d9/2895966/06d7df31afda/nihms191232f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78d9/2895966/b9293faa5498/nihms191232f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78d9/2895966/25b8c92de3d3/nihms191232f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78d9/2895966/4b2b79e74a7b/nihms191232f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78d9/2895966/dd2657e031a2/nihms191232f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78d9/2895966/4f1fdc7a5632/nihms191232f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78d9/2895966/c66403ea3788/nihms191232f8.jpg

相似文献

1
Heat shock protein 70 (hsp70) as an emerging drug target.热休克蛋白70(hsp70)作为一种新兴的药物靶点。
J Med Chem. 2010 Jun 24;53(12):4585-602. doi: 10.1021/jm100054f.
2
Insights into the function of Hsp70 chaperones.对热休克蛋白70(Hsp70)伴侣蛋白功能的深入了解。
IUBMB Life. 2001 May;51(5):283-7. doi: 10.1080/152165401317190770.
3
Hsp105alpha suppresses Hsc70 chaperone activity by inhibiting Hsc70 ATPase activity.热休克蛋白105α通过抑制热休克蛋白70(Hsc70)的ATP酶活性来抑制其伴侣活性。
J Biol Chem. 2004 Oct 1;279(40):41727-33. doi: 10.1074/jbc.M407947200. Epub 2004 Aug 2.
4
ATPases as drug targets: insights from heat shock proteins 70 and 90.作为药物靶点的ATP酶:来自热休克蛋白70和90的见解
J Med Chem. 2010 Oct 28;53(20):7280-6. doi: 10.1021/jm100342z.
5
Chemical manipulation of hsp70 ATPase activity regulates tau stability.热休克蛋白70(hsp70)ATP酶活性的化学调控可调节tau蛋白稳定性。
J Neurosci. 2009 Sep 30;29(39):12079-88. doi: 10.1523/JNEUROSCI.3345-09.2009.
6
The chaperone function of hsp70 is required for protection against stress-induced apoptosis.热休克蛋白70(hsp70)的伴侣功能是抵御应激诱导凋亡所必需的。
Mol Cell Biol. 2000 Oct;20(19):7146-59. doi: 10.1128/MCB.20.19.7146-7159.2000.
7
A small molecule inhibitor of ATPase activity of HSP70 induces apoptosis and has antitumor activities.一种HSP70 ATP酶活性的小分子抑制剂可诱导细胞凋亡并具有抗肿瘤活性。
Chem Biol. 2015 Mar 19;22(3):391-403. doi: 10.1016/j.chembiol.2015.02.004. Epub 2015 Mar 12.
8
Heat shock proteins, substrate specificity and modulation of function.热休克蛋白、底物特异性与功能调节
Protein Pept Lett. 2006;13(7):699-705. doi: 10.2174/092986606777790593.
9
[Cellular functions of cytosolic Hsp70].[胞质Hsp70的细胞功能]
Tanpakushitsu Kakusan Koso. 2004 May;49(7 Suppl):841-6.
10
OLA1 protects cells in heat shock by stabilizing HSP70.OLA1 通过稳定 HSP70 来保护热休克细胞。
Cell Death Dis. 2013 Feb 14;4(2):e491. doi: 10.1038/cddis.2013.23.

引用本文的文献

1
Participation of host cell proteins in inclusion bodies of non-segmented RNA virus infected cells: a molecular insight.宿主细胞蛋白参与非节段RNA病毒感染细胞的包涵体形成:分子层面的见解
Virol J. 2025 Aug 18;22(1):282. doi: 10.1186/s12985-025-02784-w.
2
Hepatitis C virus NS5A protein promotes the lysosomal degradation of diacylglycerol O-acyltransferase 1 (DGAT1) via endosomal microautophagy.丙型肝炎病毒NS5A蛋白通过内体微自噬促进二酰甘油O-酰基转移酶1(DGAT1)的溶酶体降解。
Autophagy Rep. 2022 Jul 22;1(1):264-285. doi: 10.1080/27694127.2022.2095591. eCollection 2022.
3
Chaperone-mediated autophagy, heat shock protein 70, and serotonin: novel targets of beta-hydroxybutyrate in HFFD/LPS-induced sporadic Alzheimer's disease model.

本文引用的文献

1
Hsp70 stabilizes lysosomes and reverts Niemann-Pick disease-associated lysosomal pathology.热休克蛋白 70 稳定溶酶体并逆转尼曼-匹克病相关的溶酶体病理。
Nature. 2010 Jan 28;463(7280):549-53. doi: 10.1038/nature08710.
2
Structure of clathrin coat with bound Hsc70 and auxilin: mechanism of Hsc70-facilitated disassembly.网格蛋白衣被与结合的 Hsc70 和辅助蛋白的结构:Hsc70 促进解组装的机制。
EMBO J. 2010 Feb 3;29(3):655-65. doi: 10.1038/emboj.2009.383. Epub 2009 Dec 24.
3
A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells.
伴侣介导的自噬、热休克蛋白70与血清素:β-羟基丁酸酯在高脂高糖饮食/脂多糖诱导的散发性阿尔茨海默病模型中的新靶点
Inflammopharmacology. 2025 May 4. doi: 10.1007/s10787-025-01754-6.
4
The Confluence of Nanotechnology and Heat Shock Protein 70 in Pioneering Glioblastoma Multiforme Therapy: Forging Pathways Towards Precision Targeting and Transformation.纳米技术与热休克蛋白70在多形性胶质母细胞瘤开创性治疗中的融合:开创精准靶向与转化之路。
Adv Pharmacol Pharm Sci. 2025 Apr 24;2025:1847197. doi: 10.1155/adpp/1847197. eCollection 2025.
5
The Molecular Mechanism of in Thermal Adaptation of Two Congeneric Oyster Species.两种同属牡蛎物种热适应性的分子机制
Int J Mol Sci. 2025 Jan 27;26(3):1109. doi: 10.3390/ijms26031109.
6
A single-cell atlas of the Culex tarsalis midgut during West Nile virus infection.西尼罗河病毒感染期间致倦库蚊中肠的单细胞图谱。
PLoS Pathog. 2025 Jan 27;21(1):e1012855. doi: 10.1371/journal.ppat.1012855. eCollection 2025 Jan.
7
Combination of HSP90 Inhibitors and HSP70 Inducers Prevent Hydrochloric Acid-Induced Pulmonary Fibrosis in Rabbits.热休克蛋白90抑制剂与热休克蛋白70诱导剂联合应用可预防家兔盐酸诱导的肺纤维化
Int J Mol Sci. 2025 Jan 7;26(2):441. doi: 10.3390/ijms26020441.
8
Bioinformatics analysis and alternative polyadenylation in Heat Shock Proteins 70 (HSP70) family members.热休克蛋白70(HSP70)家族成员的生物信息学分析与可变多聚腺苷酸化
Int J Physiol Pathophysiol Pharmacol. 2024 Dec 25;16(6):138-151. doi: 10.62347/CWPE7813. eCollection 2024.
9
Prediction of the Stability of Protein Substructures Using AI/ML Techniques.使用人工智能/机器学习技术预测蛋白质亚结构的稳定性
Methods Mol Biol. 2025;2870:153-182. doi: 10.1007/978-1-0716-4213-9_9.
10
UPF3B modulates endoplasmic reticulum stress through interaction with inositol-requiring enzyme-1α.UPF3B 通过与肌醇需求酶 1α 相互作用调节内质网应激。
Cell Death Dis. 2024 Aug 13;15(8):587. doi: 10.1038/s41419-024-06973-3.
一种新型小分子 Hsc70/Hsp70 抑制剂增强 Hsp90 抑制剂诱导的 HCT116 结肠癌细胞凋亡。
Cancer Chemother Pharmacol. 2010 Aug;66(3):535-45. doi: 10.1007/s00280-009-1194-3. Epub 2009 Dec 13.
4
Facilitating Akt clearance via manipulation of Hsp70 activity and levels.通过操纵热休克蛋白 70 的活性和水平促进 Akt 的清除。
J Biol Chem. 2010 Jan 22;285(4):2498-505. doi: 10.1074/jbc.M109.057208. Epub 2009 Nov 4.
5
Pharmacological targeting of the Hsp70 chaperone.靶向热休克蛋白 70 伴侣的药理学。
Curr Top Med Chem. 2009;9(15):1337-51. doi: 10.2174/156802609789895674.
6
Purine-scaffold Hsp90 inhibitors.嘌呤支架 HSP90 抑制剂。
Curr Top Med Chem. 2009;9(15):1436-46. doi: 10.2174/156802609789895737.
7
A small molecule inhibitor of inducible heat shock protein 70.一种诱导型热休克蛋白70的小分子抑制剂。
Mol Cell. 2009 Oct 9;36(1):15-27. doi: 10.1016/j.molcel.2009.09.023.
8
Short peptides derived from the BAG-1 C-terminus inhibit the interaction between BAG-1 and HSC70 and decrease breast cancer cell growth.源自BAG-1 C末端的短肽可抑制BAG-1与HSC70之间的相互作用,并降低乳腺癌细胞的生长。
FEBS Lett. 2009 Nov 3;583(21):3405-11. doi: 10.1016/j.febslet.2009.09.047. Epub 2009 Oct 1.
9
Chemical manipulation of hsp70 ATPase activity regulates tau stability.热休克蛋白70(hsp70)ATP酶活性的化学调控可调节tau蛋白稳定性。
J Neurosci. 2009 Sep 30;29(39):12079-88. doi: 10.1523/JNEUROSCI.3345-09.2009.
10
Hsp70 molecular chaperones and Parkinson's disease.热休克蛋白 70 分子伴侣与帕金森病。
Biopolymers. 2010 Mar;93(3):218-28. doi: 10.1002/bip.21302.