Isaacs Hart
Department of Pathology, Rady Children's Hospital San Diego, CA 92123, USA.
Fetal Pediatr Pathol. 2010 Jan;29(2):99-107. doi: 10.3109/15513811003620856.
Adrenocortical tumors occur less often in the fetus and newborn than later in life. The purpose of this study was to focus on the fetus and newborn in an attempt to determine the various ways these tumors differ in their biologic behavior, pathology, clinical presentation and response to therapy from those occurring in the older child and adolescent. Twenty-five fetuses and newborns were diagnosed with ACTs prenatally (n = 3) and in the newborn period (n = 22). The study consisted of two main neoplasms: adrenocortical adenoma, 24%, and adrenocortical carcinoma, 76%. The most common presenting finding was an abdominal mass. Overall survival for patients with ACA and ACC were 33% and 53%, respectively.
肾上腺皮质肿瘤在胎儿和新生儿中的发生率低于生命后期。本研究的目的是聚焦于胎儿和新生儿，试图确定这些肿瘤在生物学行为、病理学、临床表现以及对治疗的反应方面与大龄儿童和青少年所患肿瘤有何不同。25例胎儿和新生儿在产前（n = 3）和新生儿期（n = 22）被诊断为肾上腺皮质肿瘤。该研究包括两种主要肿瘤：肾上腺皮质腺瘤，占24%，以及肾上腺皮质癌，占76%。最常见的表现是腹部肿块。肾上腺皮质腺瘤和肾上腺皮质癌患者的总体生存率分别为33%和53%。
