Bertolotto Alessandra, Volpe Laura, Calianno Alessandra, Pugliese Maria Cristina, Lencioni Cristina, Resi Veronica, Ghio Alessandra, Corfini Marisa, Benzi Luca, Del Prato Stefano, Di Cianni Graziano
Section of Diabetes.
J Matern Fetal Neonatal Med. 2010 Nov;23(11):1310-4. doi: 10.3109/14767051003678150.
We designed this study to assess the potential effects of physical activity and dietary habits on glucose tolerance during pregnancy.
This is an observational study involving 268 women who underwent a 50-g oral glucose challenge test (GCT) at 27±6.9 week of gestation. Plasma glucose level at 1-h GCT ≥ 140 mg/dl was used to define abnormal glucose tolerance (AGT). Physical activity was evaluated using the short form of the International Physical Activity Questionnaire (IPAQ), while for dietary habits we used a food frequency questionnaire linked to a computerised program.
One hundred five women had AGT (AGT+) and 163 had normal glucose tolerance (AGT−). There was no difference between the two groups in demographic and clinical data, with the exception of pre-pregnancy BMI and weight gain both higher in AGT+ women. Also, all parameters referring to physical activity energy and diet (Kcal and diet components) were not statistically different between the two groups. After a multivariate analysis, only pre-pregnancy BMI (F-value 9.264, p=0.002) remained an independent predictor of 1-h plasma glucose.
Our study suggests that high pre-pregnancy BMI confers a substantially high risk of AGT, independently of lifestyle during pregnancy.
我们开展本研究以评估孕期身体活动和饮食习惯对糖耐量的潜在影响。
这是一项观察性研究，纳入了268名在妊娠27±6.9周时接受50克口服葡萄糖耐量试验（GCT）的女性。1小时GCT时血浆葡萄糖水平≥140毫克/分升被用于定义糖耐量异常（AGT）。使用国际体力活动问卷（IPAQ）简表评估身体活动，而对于饮食习惯，我们使用了与计算机程序相关联的食物频率问卷。
105名女性存在AGT（AGT+），163名女性糖耐量正常（AGT−）。两组在人口统计学和临床数据方面无差异，但AGT+组女性的孕前BMI和体重增加更高。此外，两组在所有与身体活动能量和饮食（千卡和饮食成分）相关的参数上均无统计学差异。多因素分析后，只有孕前BMI（F值9.264，p = 0.002）仍然是1小时血浆葡萄糖的独立预测因素。
我们的研究表明，孕前BMI高会带来较高的AGT风险，且独立于孕期生活方式。
