使用液体尼古丁输送产品促进戒烟。

Use of a liquid nicotine delivery product to promote smoking cessation.

机构信息

Department of Medical Oncology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

出版信息

BMC Public Health. 2010 Mar 24;10:155. doi: 10.1186/1471-2458-10-155.

DOI:10.1186/1471-2458-10-155

PMID:20334673

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2858116/

Abstract

BACKGROUND

Despite access to various pharmacotherapies and counseling support to aid cessation, smokers typically demonstrate quit rates below 50%. This report describes the results of a Phase 2a study exploring the efficacy of a liquid nicotine delivery system as an aid to smoking cessation assessed after 12 weeks of therapy.

METHODS

A single-arm Phase 2a study was conducted. Community-based smokers (ages 18+ years, smoking at least 10 cigarettes daily for the past year and interested in making a quit attempt) were recruited and completed clinic visits at 2 week intervals over the 12 week study period where carbon monoxide levels were assessed and the Smoke-Break product was rated on taste and overall satisfaction. Participants were provided with a supply of liquid nicotine cigarettes (e.g., Smoke-Break) at each clinic visit. A total of 69 smokers were enrolled and received the intervention product (intention to treat group, ITT) and 52 smokers verified participation (according to protocol group, ATP).

RESULTS

The cessation rate at 12 weeks after the baseline visit, assessed as the bioverified point prevalence of abstinence, was 71.1% (95% confidence interval [CI] 58.8%-83.5%) in the ATP group and 53.6% (41.8%-65.4%) in the ITT group. Participants rated the liquid nicotine delivery system highly and also expressed general satisfaction. Few adverse events were identified with no serious adverse events.

CONCLUSIONS

These results support the efficacy of the liquid nicotine delivery system in smoking cessation. If this nicotine delivery product proves to be effective in larger trials, it could represent an inexpensive, readily accessible and well-tolerated agent to promote smoking cessation.

摘要

背景

尽管有多种药物治疗和咨询支持来帮助戒烟，但吸烟者通常表现出的戒烟率低于 50%。本报告描述了一项探索液体尼古丁递送系统作为戒烟辅助手段的疗效的 2a 期研究结果，该研究在 12 周治疗后进行评估。

方法

进行了一项单臂 2a 期研究。社区吸烟者（年龄 18 岁以上，过去一年中每天至少吸烟 10 支，并有戒烟意愿）被招募，并在 12 周的研究期间每隔 2 周进行一次临床访视，评估一氧化碳水平，并对 Smoke-Break 产品的口感和总体满意度进行评分。参与者在每次就诊时都会获得液体尼古丁香烟（例如 Smoke-Break）的供应。共有 69 名吸烟者入组并接受了干预产品（意向治疗组，ITT），52 名吸烟者根据方案（根据协议组，ATP）确认参与。