Department of Surgical Oncology (Division of Urology), University Health Network, Princess Margaret Hospital, and the University of Toronto, Toronto, Ontario, Canada.
Eur Urol. 2010 Jul;58(1):173-7. doi: 10.1016/j.eururo.2010.03.006. Epub 2010 Mar 12.
Two patients with low-risk prostate cancer (PCa) were treated with outpatient in-bore magnetic resonance imaging (MRI)-guided focal laser ablation. The tumor was identified on MRI. A laser fiber was delivered via a catheter inserted through a perineal template and guided to the target with MRI. The tissue temperature was monitored during laser ablation by MRI thermometry. Accumulated thermal damage was calculated in real time. Immediate post-treatment contrast-enhanced MRI confirmed devascularization of the target. No adverse events were noted. MRI-guided focal laser therapy of low-risk PCa is feasible and may offer a good balance between cancer control and side effects.
两名低危前列腺癌 (PCa) 患者接受了门诊磁共振成像 (MRI) 引导下的聚焦激光消融治疗。肿瘤在 MRI 上被识别。激光光纤通过经会阴模板插入的导管递送至 MRI 引导的目标。在激光消融过程中，通过 MRI 测温仪监测组织温度。实时计算累积热损伤。即刻治疗后增强 MRI 证实了靶区的血管化。未观察到不良事件。MRI 引导下的低危 PCa 聚焦激光治疗是可行的，可能在癌症控制和副作用之间取得良好平衡。
