Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, IL, USA.
Epilepsy Behav. 2010 Apr;17(4):436-40. doi: 10.1016/j.yebeh.2010.02.007. Epub 2010 Mar 23.
One proposed cause of sudden unexpected death in epilepsy (SUDEP) in patients is generalized convulsive seizures with respiratory malfunction. We evaluated DBA/1 mice as a chronic SUDEP model. In DBA/1 mice, audiogenic seizures induced by acoustic stimulation resulted in generalized convulsive seizures followed by respiratory arrest from postnatal day (PND) 21 to 100. The incidence of respiratory arrest susceptibility increased, reaching approximately 90-100% by three to seven daily seizures when testing began on PND 21-30. Respiratory arrest was reversible with resuscitation in approximately 98% of mice, which allows repeated seizure testing. Electrocardiographic activity in DBA/1 mice was detectable for approximately 4-6 minutes after respiratory arrest, indicating that death is likely due to respiratory cessation, as cardiac changes occur later. These findings suggest that DBA/1 mice are a useful chronic SUDEP model. These mice die suddenly from respiratory arrest after generalized convulsive seizures until reaching PND >or=100, allowing testing of chronic preventive treatments for SUDEP.
有一种癫痫猝死（SUDEP）的成因假设是全身性惊厥伴有呼吸功能障碍。我们评估 DBA/1 小鼠作为慢性 SUDEP 模型。在 DBA/1 小鼠中，由声音刺激引发的听觉性癫痫发作导致全身性惊厥，继而在出生后第 21 至 100 天出现呼吸暂停。呼吸暂停易感性的发生率增加，当从出生后第 21-30 天开始每天进行 3-7 次癫痫发作测试时，约有 90-100%的小鼠发生呼吸暂停。大约 98%的呼吸暂停小鼠可通过复苏恢复呼吸，这允许重复进行癫痫发作测试。DBA/1 小鼠的心电图活动在呼吸暂停后大约可检测到 4-6 分钟，表明死亡很可能是由于呼吸停止，因为心脏变化发生在后。这些发现表明 DBA/1 小鼠是一种有用的慢性 SUDEP 模型。这些小鼠在全身性惊厥后突然死于呼吸暂停，直到达到出生后第 100 天以上，从而可以测试慢性预防 SUDEP 的治疗方法。
