细胞色素P4502D6基因多态性与海洛因海绵状白质脑病易感性的关联
[Association of cytochrome P4502D6 gene polymorphism with the susceptibility of heroin spongiform leucoencephalopathy].
作者信息
Zhou Liang, Lu Bing-xun, Yin Ja
机构信息
Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
出版信息
Nan Fang Yi Ke Da Xue Xue Bao. 2010 Mar;30(3):572-4, 583.
OBJECTIVE
To elucidate the relation between cytochrome P4502D6 (CYP2D6) gene polymorphism and the susceptibility of heroin spongiform leucoencephalopathy (HSLE).
METHODS
With polymerase chain reaction-restriction fragment length polymorphism technique, the cytochrome P4502D6 gene polymorphisms were analyzed in HSLE cases and control subjects.
RESULTS
The frequencies of CYP2D6 (CYP2D6/C188, CYP2D6/L2938, CYP2D6/G4268) gene mutations were higher in HSLE patients than in the controls.
CONCLUSION
The CYP2D6 gene mutation is associated with a high risk of HSLE.
目的
阐明细胞色素P4502D6（CYP2D6）基因多态性与海洛因海绵状白质脑病（HSLE）易感性之间的关系。
方法
采用聚合酶链反应-限制性片段长度多态性技术，分析HSLE病例和对照受试者的细胞色素P4502D6基因多态性。
结果
HSLE患者中CYP2D6（CYP2D6/C188、CYP2D6/L2938、CYP2D6/G4268）基因突变频率高于对照组。
结论
CYP2D6基因突变与HSLE的高风险相关。
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