Department of Paediatric Medicine, Royal Manchester Children's Hospital, Oxford Road, Manchester M13 9WL, UK.
Arch Dis Child. 2010 Apr;95(4):281-5. doi: 10.1136/adc.2008.151555.
Altered growth, body composition and abnormalities of skeletal mineralisation have been reported in offspring of mothers with type 1 and type 2 diabetes mellitus.
The authors hypothesised that children born to mothers with type 1 diabetes mellitus (CDM) would be taller, have higher body mass index (BMI), greater fat mass, thicker diaphyseal bone cortices and reduced trabecular bone mineral density (BMD), as compared to those born to non-diabetic mothers.
Anthropometric, body composition and bone parameters were assessed using dual-energy x-ray absorptiometry (DXA) and peripheral quantitative CT in 67 white Caucasian CDM (35 boys; age 5-18 years) and in 246 (121 boys) age-matched controls.
CDM were taller (p<0.0001), heavier (p<0.0001) and had higher BMI (p=0.02), and had 32% more total body fat mass and 7.5% more total body lean mass than controls. At the total body and lumbar spine (L1-L4) sites, CDM had significantly higher bone area and bone mineral content compared with controls. However, areal BMD at both these sites and lumbar spine bone mineral apparent density were not significantly different in the two groups, indicating that CDM have bigger bones compared with controls but their mineral content per unit area or volume is not substantially different. The distal radial trabecular and total volumetric BMD in CDM was not demonstrably different from controls. At the mid-radius, both periosteal (2.4%; p=0.03) and endosteal circumferences (5.7%; p=0.02) were bigger in CDM compared with controls.
The authors speculate that the intrauterine diabetic environment is associated with an increase in linear growth, adiposity and larger bone dimensions during childhood and adolescence.
已有研究报道，1 型和 2 型糖尿病母亲所生后代的生长、身体成分和骨骼矿物质化异常。
作者假设，与非糖尿病母亲所生的孩子相比，1 型糖尿病母亲（CDM）所生的孩子会长得更高，体重指数（BMI）更高，体脂更多，骨干皮质更厚，骨小梁骨密度（BMD）更低。
采用双能 X 射线吸收法（DXA）和外周定量 CT 对 67 名白种人 CDM（35 名男孩；年龄 5-18 岁）和 246 名（121 名男孩）年龄匹配的对照组的人体测量学、身体成分和骨骼参数进行评估。
CDM 更高（p<0.0001）、更重（p<0.0001）、BMI 更高（p=0.02），全身总脂肪量多 32%，全身瘦体重多 7.5%。与对照组相比，CDM 全身和腰椎（L1-L4）部位的骨面积和骨矿物质含量明显更高。然而，两组在这些部位和腰椎的骨面积密度均无显著差异，表明与对照组相比，CDM 有更大的骨骼，但单位面积或体积的矿物质含量并无明显差异。CDM 远端桡骨小梁和总容积 BMD 与对照组无明显差异。在桡骨中段，与对照组相比，骨膜（2.4%；p=0.03）和内骨（5.7%；p=0.02）周长更大。
作者推测，宫内糖尿病环境与儿童和青少年时期线性生长、肥胖和更大的骨骼尺寸增加有关。
