Nephrology, Saint Louis Hospital, 1 Avenue Claude Vellefaux, 75010 Paris, France.
Nephrol Dial Transplant. 2010 Jun;25(6):2026-8. doi: 10.1093/ndt/gfq153. Epub 2010 Mar 24.
We describe a 35-year-old woman who presented with proteinuria and microscopic haematuria. Blood tests revealed a low C3 complement level, with no evidence of cryoglobulin. Renal biopsy showed a Type 1 membranoproliferative glomerulonephritis (MPGN) with isolated C3 deposits on immunofluorescence study. Bone marrow aspirate, done for monocytopenia, was consistent with a diagnosis of hairy cell leukaemia (HCL). Both haematological and nephrological diseases completely responded to treatment with cladribine, strongly suggesting that the renal disease was a paraneoplastic syndrome. To our knowledge, this is the first report of a non-cryoglobulinaemic MPGN associated to HCL.
我们描述了一位 35 岁女性，她表现为蛋白尿和镜下血尿。血液检查显示 C3 补体水平低，无冷球蛋白血症证据。肾活检显示 1 型膜增生性肾小球肾炎（MPGN），免疫荧光研究显示仅有 C3 沉积。骨髓抽吸术用于单核细胞减少症，诊断为毛细胞白血病（HCL）。血液学和肾脏病学疾病均完全对克拉屈滨治疗有反应，强烈提示肾脏疾病是副肿瘤综合征。据我们所知，这是首例与 HCL 相关的非冷球蛋白血症性 MPGN 报告。
