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S-adenosyl-L-homocysteine hydrolase as a target for antiviral chemotherapy.

作者信息

Wolfe M S, Borchardt R T

机构信息

Department of Medicinal Chemistry, University of Kansas, Lawrence 66045.

出版信息

J Med Chem. 1991 May;34(5):1521-30. doi: 10.1021/jm00109a001.

DOI:10.1021/jm00109a001
PMID:2033576
Abstract
摘要

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Homocysteine potentiates the antiviral and cytostatic activity of those nucleoside analogues that are targeted at S-adenosylhomocysteine hydrolase.
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[Synthesis of S-9-(2,3-dihydroxypropyl)adenine (DHPA) analogs and their inhibition of S-adenosyl-L-homocysteine (SAH) hydrolase].[S-9-(2,3-二羟基丙基)腺嘌呤（DHPA）类似物的合成及其对S-腺苷-L-高半胱氨酸（SAH）水解酶的抑制作用]
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