Department of Cardiovascular Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
ASAIO J. 2010 May-Jun;56(3):254-9. doi: 10.1097/MAT.0b013e3181d0ec21.
We have developed an ultraminiature centrifugal pump, TinyPump, with a priming volume of 5 ml. The in vivo performance of TinyPump was compared with that of HPM-05 for left ventricular support. Each pump group included seven rabbits weighing 3.4-3.8 kg. One rabbit in the TinyPump group and two rabbits in the HPM-05 group died of unsuccessful cannulation. The remaining rabbits (six in the TinyPump group and five in the HPM-05 group) were instrumented and observed for 240 minutes. The pump flow was maintained at around 200 ml/min. The priming volumes of the entire circuits were 25 and 45 ml for TinyPump and HPM-05, respectively. TinyPump required a higher rotation speed (2214 +/- 47 vs. 1261 +/- 87 rpm, p < 0.05) because of its small priming volume but showed a similar plasma free hemoglobin level to HPM-05. The hematocrit values were kept higher in the TinyPump group during ventricular support (24.3 +/- 1.4% vs. 20.1 +/- 1.4% at 240 minutes, p < 0.05). The mean arterial pressure did not differ between the two groups. The biochemical parameters were also equivalent in the two groups. Overall, TinyPump exhibited a feasible in vivo performance. This ultraminiature device would offer promising outcomes for neonates and infants with intractable heart failure.
我们开发了一种微型离心栗，名为 TinyPump，其预充体积为 5ml。将 TinyPump 的体内性能与 HPM-05 进行比较，用于左心室支持。每组泵包括 7 只体重为 3.4-3.8kg 的兔子。TinyPump 组中有一只兔子和 HPM-05 组中有两只兔子因插管不成功而死亡。其余兔子（TinyPump 组 6 只，HPM-05 组 5 只）进行了仪器操作并观察 240 分钟。栗的流量保持在 200ml/min 左右。整个循环的预充体积分别为 TinyPump 和 HPM-05 的 25ml 和 45ml。由于其较小的预充体积，TinyPump 需要更高的转速（2214+/-47 比 1261+/-87rpm，p<0.05），但与 HPM-05 相比，其血浆游离血红蛋白水平相似。在心室支持期间，TinyPump 组的红细胞压积值保持较高（240 分钟时为 24.3+/-1.4%比 20.1+/-1.4%，p<0.05）。两组间平均动脉压无差异。两组的生化参数也相当。总的来说，TinyPump 表现出可行的体内性能。这种超微型装置为患有难治性心力衰竭的新生儿和婴儿提供了有希望的治疗结果。
