Department of Pharmaceutical Chemistry, Semmelweis University, Hogyes E.u.9., Budapest H-1092, Hungary.
Molecules. 2010 Feb 5;15(2):824-33. doi: 10.3390/molecules15020824.
Ceramides play a crucial role in the barrier function of the skin as well as in transmembrane signaling. In this study long aliphatic chain tartaric acid diamides able to replace ceramides in an in vitro model of the stratum corneum lipid matrix due to their similar physico-chemical properties were synthesized from diacetoxysuccinic anhydride in four steps. Their pro-apoptotic effect on fibroblast cells was also investigated.
神经酰胺在皮肤的屏障功能以及跨膜信号转导中起着至关重要的作用。在这项研究中，由于其相似的物理化学性质，从二乙酰琥珀酸酐出发，经四步反应合成了能够在角质层脂质基质的体外模型中替代神经酰胺的长链脂肪二酸二酰胺。还研究了它们对成纤维细胞的促凋亡作用。
