使用一种新的权重计算方案评估相似因子的数学方法。
Mathematical approach for the assessment of similarity factor using a new scheme for calculating weight.
作者信息
Gohel M C, Sarvaiya K G, Shah A R, Brahmbhatt B K
机构信息
Department of Pharmaceutics and Pharmaceutical Technology, L. M. College of Pharmacy, Navrangpura, Ahmedabad-380 009, India.
出版信息
Indian J Pharm Sci. 2009 Mar;71(2):142-4. doi: 10.4103/0250-474X.54281.
The objective of the present work was to propose a method for calculating weight in the Moore and Flanner Equation. The percentage coefficient of variation in reference and test formulations at each time point was considered for calculating weight. The literature reported data are used to demonstrate applicability of the method. The advantages and applications of new approach are narrated. The results show a drop in the value of similarity factor as compared to the approach proposed in earlier work. The scientists who need high accuracy in calculation may use this approach.
本研究的目的是提出一种计算摩尔和弗拉纳方程中权重的方法。计算权重时考虑了每个时间点参考制剂和测试制剂的变异系数百分比。文献报道的数据用于证明该方法的适用性。叙述了新方法的优点和应用。结果表明，与早期工作中提出的方法相比，相似因子的值有所下降。需要高精度计算的科学家可以使用这种方法。
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