Clinical Rheumatology IVa, Institute of Rheumatology, School of Medicine, University of Belgrade, Belgrade, Serbia and Montenegro.
Mod Rheumatol. 2010 Aug;20(4):353-7. doi: 10.1007/s10165-010-0285-7. Epub 2010 Mar 25.
This study aimed to assess symptoms of depression and anxiety in Serbian patients with systemic sclerosis (SSc) and to estimate the impact of disease severity and socioeconomic factors on development of depression and anxiety in SSc. Thirty-five patients with SSc and 30 age- and gender-matched healthy individuals participated. Symptoms of depression and anxiety were evaluated using the Beck's depression inventory and Zung's anxiety self-assessment scale. We estimated the impact of gender, age, economic status, marital status, disease duration, disease subset (limited or diffuse), and some clinical features on development of depressive symptoms and anxiety in patients with SSc. Symptoms of depression were found in 68.6% of patients (compared with 23.3% in the control group), were more frequent in patients with longer disease duration and in female and older patients, and were more common in unemployed and retired patients than in employed individuals. No differences in anxiety and depressive symptoms was noticed between patients with limited and diffuse SSc or those with or without restrictive lung disease, pulmonary hypertension, finger-tip ulcers, and heart involvement. Symptoms of depression were associated with severe pain. Symptoms of anxiety were found in 80% of patients compared with 13.3% of healthy individuals and were equally as frequent in patients of different gender, age, socioeconomic status, and disease duration and severity. Symptoms of depression and anxiety are common in Serbian patients with SSc. Depressive symptoms depended mostly on socioeconomic factors, disease duration, and pain intensity, whereas disease severity had no significant impact on development of depressive symptoms and anxiety.
本研究旨在评估塞尔维亚系统性硬化症（SSc）患者的抑郁和焦虑症状，并评估疾病严重程度和社会经济因素对 SSc 患者抑郁和焦虑发展的影响。35 名 SSc 患者和 30 名年龄和性别匹配的健康个体参与了研究。使用贝克抑郁量表和宗氏焦虑自评量表评估抑郁和焦虑症状。我们评估了性别、年龄、经济状况、婚姻状况、疾病持续时间、疾病亚型（局限型或弥漫型）以及一些临床特征对 SSc 患者发生抑郁症状和焦虑的影响。研究发现，68.6%的患者存在抑郁症状（对照组为 23.3%），疾病持续时间较长、女性和年龄较大的患者抑郁症状更为常见，失业和退休患者比在职患者更常见。局限型和弥漫型 SSc 患者、有或无限制性肺病、肺动脉高压、指尖溃疡和心脏受累患者之间，焦虑和抑郁症状无差异。抑郁症状与严重疼痛相关。80%的患者存在焦虑症状，而健康个体中为 13.3%，不同性别、年龄、社会经济状况以及疾病持续时间和严重程度的患者焦虑症状发生率相同。抑郁和焦虑症状在塞尔维亚 SSc 患者中很常见。抑郁症状主要取决于社会经济因素、疾病持续时间和疼痛强度，而疾病严重程度对抑郁症状和焦虑的发展没有显著影响。
