Hickey W F, Hsu B L, Kimura H
Department of Pathology, Washington University School of Medicine, Saint Louis, Missouri 63110.
J Neurosci Res. 1991 Feb;28(2):254-60. doi: 10.1002/jnr.490280213.
The entry of T-lymphocytes into the parenchyma of the central nervous system is a critical early feature in the pathogenesis of many experimental and spontaneously occurring immune-mediated illnesses. The physiological mechanisms controlling this entry have not been elucidated. This study reports that T-cell entry into the rat CNS appears to be primarily dependent upon the activation state of the lymphocytes; T-lymphoblasts enter the CNS (and all other tissues examined) in an apparently random manner while T cells not in blast phase are excluded. Antigen specificity, MHC compatibility, T-cell phenotype, and T-cell receptor gene usage do not appear related to the ability of cells to enter. This study demonstrates that when T-lymphoblasts are introduced into the circulation they rapidly appear in the CNS tissue. Their concentration in the CNS reaches a peak between 9 and 12 hr, and lymphocytes which have entered, exit within 1 to 2 days. Cells capable of reacting with a CNS antigen remain in the tissue or cyclically reenter to initiate inflammation if they are able to recognize their antigen in the correct MHC context. This observation also appears to pertain to the entry of activated T cells into many other tissues, although their concentrations in these non-CNS sites was not quantitated.
T淋巴细胞进入中枢神经系统实质是许多实验性和自发性免疫介导疾病发病机制中的一个关键早期特征。控制这种进入的生理机制尚未阐明。本研究报告称，T细胞进入大鼠中枢神经系统似乎主要取决于淋巴细胞的激活状态；T淋巴母细胞以明显随机的方式进入中枢神经系统（以及所有其他检查的组织），而未处于母细胞阶段的T细胞则被排除在外。抗原特异性、MHC相容性、T细胞表型和T细胞受体基因使用情况似乎与细胞进入的能力无关。本研究表明，当将T淋巴母细胞引入循环时，它们会迅速出现在中枢神经系统组织中。它们在中枢神经系统中的浓度在9至12小时之间达到峰值，进入的淋巴细胞在1至2天内离开。能够与中枢神经系统抗原发生反应的细胞会留在组织中，或者如果它们能够在正确的MHC背景下识别其抗原，则会周期性地重新进入以引发炎症。这一观察结果似乎也适用于活化T细胞进入许多其他组织，尽管它们在这些非中枢神经系统部位的浓度未进行定量。
