Laboratory for the Study of Calcified Tissues and Biomaterials, Faculty of Dentistry, Université de Montréal, 2900, boul. Edouard-Montpetit, Pavillon Roger-Gaudry, Montréal, Québec H3T 1J4, Canada.
J Biomed Mater Res B Appl Biomater. 2010 Jul;94(1):64-71. doi: 10.1002/jbm.b.31624.
Porous metals (sintered beads and meshes) have been used for many years for different orthopedic applications. Metal foams have been recently developed. These foams have the advantage of being more porous than the traditional coatings. Their high porosity provides more space for bone ingrowth and mechanical interlocking and presents more surface for implant-bone contact. The objective of this study was to evaluate in vivo bone ingrowth into Ti implants covered with a novel Ti foam coating. This foam contains 50% in volume of interconnected pores and a higher surface area compared to dense Ti. Both coated implants and dense Ti controls were placed transcortically in the rat tibia. The animals were sacrificed at 2 weeks after implantation, and the amount of bone in the implants was determined using backscattered electron imaging and X-ray microtomography. Already at this time interval, the pores within the Ti foam showed 97.7% bone filling, and the bone-implant contact area was significantly increased compared to dense Ti controls. These initial results indicate that this novel Ti foam is biocompatible, has the capacity to sustain bone formation, and can potentially improve osseointegration.
多孔金属（烧结珠和网）已被用于许多年的不同骨科应用。金属泡沫最近已经开发出来。这些泡沫的优点是比传统涂层具有更高的多孔性。它们的高多孔性为骨长入和机械互锁提供了更多的空间，并为植入物-骨接触提供了更多的表面。本研究的目的是评估新型钛泡沫涂层 Ti 植入物的体内骨长入情况。这种泡沫的体积含有 50%的连通孔，比致密 Ti 具有更高的表面积。涂层植入物和致密 Ti 对照物均经皮骨植入大鼠胫骨。在植入后 2 周处死动物，使用背散射电子成像和 X 射线微断层扫描来确定植入物中的骨量。在这个时间间隔内，Ti 泡沫内的孔已经达到 97.7%的骨填充，与致密 Ti 对照组相比，骨-植入物接触面积显著增加。这些初步结果表明，这种新型钛泡沫具有生物相容性、能够维持骨形成的能力，并可能改善骨整合。
