[β-1-24促肾上腺皮质激素对大鼠代偿性肾肥大的增强作用]
[Enhancement of compensatory renal hypertrophy by beta-1-24 corticotropin in the rat].
作者信息
Reville P, Stephan F, de Laharpe F, Compagnie M J
出版信息
C R Seances Soc Biol Fil. 1977;171(5):1122-8.
PMID:203374
Abstract
In the rat, the administration of beta1-24-corticotrophin during 7 days following an uninephrectomy enhances significantly the compensatory hypertrophy of the remaining kidney. There is no increase in renal compensatory hypertrophy when ACTH is injected to previously adrenalectomized rats. This action of ACTH could be related to the diabetes mellitus induced by this hormone or to an increase in sodium reabsorption by the tubular epithelial cells.
摘要
在大鼠中，单侧肾切除术后7天内给予β1-24促肾上腺皮质激素可显著增强剩余肾脏的代偿性肥大。给先前已切除肾上腺的大鼠注射促肾上腺皮质激素时，肾脏代偿性肥大并无增加。促肾上腺皮质激素的这一作用可能与该激素诱发的糖尿病有关，或者与肾小管上皮细胞对钠重吸收的增加有关。
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