人类免疫缺陷病毒-1 转基因大鼠中多巴胺能发育改变的证据。
Evidence for developmental dopaminergic alterations in the human immunodeficiency virus-1 transgenic rat.
机构信息
Department of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine.
出版信息
J Neurovirol. 2010 Mar;16(2):168-73. doi: 10.3109/13550281003690177.
Abstract
Neurologic impairments associated with human immunodeficiency virus (HIV) infection in pediatric patients may affect quality of life, and can develop despite antiretroviral therapy (ART). Behavioral changes observed in clinical studies of HIV-infected children suggest alterations in dopaminergic neurotransmission. Findings from our model of choice, the HIV-1 transgenic rat, reveal a significant increase in phosphorylated tyrosine hydroxylase protein expression and a decrease in dopamine transporter mRNA, without changes in tyrosine hydroxylase (TH) or dopamine transporter (DAT) protein or in more general markers of protein and gene expression levels in the HIV-1 transgenic rat midbrain. Thus these findings suggest selective vulnerability of the dopamine system in developing brains to HIV-1 infection.
摘要
与小儿人类免疫缺陷病毒 (HIV) 感染相关的神经功能障碍可能会影响生活质量，并且尽管有抗逆转录病毒疗法 (ART)，但仍可能会出现。在 HIV 感染儿童的临床研究中观察到的行为变化表明多巴胺能神经传递发生改变。我们选择的模型，即 HIV-1 转基因大鼠的研究结果表明，磷酸酪氨酸羟化酶蛋白表达显著增加，多巴胺转运体 mRNA 减少，而 HIV-1 转基因大鼠中脑的酪氨酸羟化酶 (TH) 或多巴胺转运体 (DAT) 蛋白或更一般的蛋白质和基因表达水平标志物没有变化。因此，这些发现表明多巴胺系统在发育中的大脑中对 HIV-1 感染具有选择性易损性。
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