围产期营养与抗感染免疫。
Perinatal nutrition and immunity to infection.
机构信息
Department of Paediatrics, Imperial College, and Imperial College Healthcare NHS Trust, London, UK.
出版信息
Pediatr Allergy Immunol. 2010 Jun;21(4 Pt 1):564-76. doi: 10.1111/j.1399-3038.2010.01002.x. Epub 2010 Mar 19.
Abstract
Epidemiological data provide strong evidence for a relationship between undernutrition and life-threatening infection in infants and children. However, the mechanisms that underlie this relationship are poorly understood. Through foetal life, infancy and childhood, the immune system undergoes a process of functional maturation. The adequacy of this process is dependent on environmental factors, and there is accumulating evidence of the impact of pre- and post-natal nutrition in this regard. This review outlines the impact of nutrition during foetal and infant development on the capacity to mount immune responses to infection. It provides an overview of the epidemiologic evidence for such a role and discusses the possible mechanisms involved.
摘要
流行病学数据为营养不良与婴儿和儿童的生命威胁性感染之间的关系提供了有力证据。然而，这种关系背后的机制还不太清楚。从胎儿期到婴儿期和儿童期，免疫系统经历一个功能成熟的过程。这个过程的充分性取决于环境因素，越来越多的证据表明产前和产后营养在这方面有影响。这篇综述概述了胎儿和婴儿发育过程中的营养对免疫反应感染能力的影响。它提供了这种作用的流行病学证据概述，并讨论了可能涉及的机制。
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