Department of Human Nutrition, Faculty of Biotechnology and Food Science, Wroclaw University of Environmental and Life Sciences, 51-630 Wrocław, Poland.
Institute of Health Sciences, Collegium Salutis Humanae, University of Opole, 45-060 Opole, Poland.
Nutrients. 2023 Apr 15;15(8):1908. doi: 10.3390/nu15081908.
The nutritional status of pregnant women is considered to affect fetal development and the health condition of newborns, including their immune system. We investigated the relationship between the concentrations of magnesium (Mg), calcium (Ca), zinc (Zn), iron (Fe) and copper (Cu) in maternal serum (MS) and the concentrations of IgG antibodies and antineutrophil cytoplasmatic auto-antibodies against lactoferrin (Lf-ANCA) in umbilical cord serum (UCS). IgG was considered as a promoter of immunity, and Lf-ANCA as an inhibitor. The examined group consisted of 98 pregnant women and their healthy term newborn children. The concentrations of mineral elements were measured by FAAS/FAES, while the concentrations of antibodies were determined by ELISA. Excessive MS Fe and insufficient MS Cu were related to insufficient UCS IgG and excessive UCS Lf-ANCA. The correlation analysis showed confirming results. Adequate UCS IgG and Lf-ANCA were related to MS Mg at the strictly lower limit of the reference values. The results obtained seem to suggest that an excess of Fe and a deficiency of Cu in pregnancy may adversely affect some immune parameters of newborns. Reference values for MS Mg are likely to require reconsideration. It would be advisable to monitor the nutritional status of pregnant women with minerals in order to support the immune capacity of newborns.
孕妇的营养状况被认为会影响胎儿的发育和新生儿的健康状况，包括他们的免疫系统。我们研究了母体血清（MS）中镁（Mg）、钙（Ca）、锌（Zn）、铁（Fe）和铜（Cu）的浓度与脐血血清（UCS）中 IgG 抗体和乳铁蛋白抗中性粒细胞胞浆抗体（Lf-ANCA）的浓度之间的关系。IgG 被认为是免疫的促进剂，而 Lf-ANCA 则是免疫的抑制剂。检查组包括 98 名孕妇及其健康的足月新生儿。通过火焰原子吸收光谱法/火焰原子发射光谱法测量矿物质元素的浓度，通过酶联免疫吸附试验测定抗体的浓度。过多的 MS Fe 和不足的 MS Cu 与不足的 UCS IgG 和过多的 UCS Lf-ANCA 有关。相关分析显示了确认的结果。足够的 UCS IgG 和 Lf-ANCA 与 MS Mg 在参考值的严格下限有关。研究结果表明，怀孕期间 Fe 过量和 Cu 缺乏可能会对新生儿的某些免疫参数产生不利影响。MS Mg 的参考值可能需要重新考虑。监测孕妇的矿物质营养状况以支持新生儿的免疫能力是明智的。
