Stevens R H, Loven D P, Osborne J W, Prall J P, Lawson A J
Cancer Lett. 1978 Jan;4(1):27-33. doi: 10.1016/s0304-3835(78)93192-0.
The intracellular concentrations of adenosine 3',5'-cyclic monophosphate (cAMP) in colonic tumors induced in adult male Holtzman rats by 1,2-dimethylhydrazine (DMH) were found to be 1/2 the concentration found in normal large bowel tissue. Intracellular concentrations of guanosine 3'-5'-cyclic monophosphate (cGMP) in the neoplastic cells were twice the normal colon level. The concentrations of these two cyclic nucleotides were relatively constant throughout the normal colon. Thus, the anomalous tumor cyclic nucleotide concentrations are attributed to the specific cell population of the lesion and not to the site of development within the colon.
成年雄性霍尔兹曼大鼠经1,2 - 二甲基肼（DMH）诱导产生的结肠肿瘤中，3',5'-环磷酸腺苷（cAMP）的细胞内浓度为正常大肠组织中浓度的二分之一。肿瘤细胞中3',5'-环磷酸鸟苷（cGMP）的细胞内浓度是正常结肠水平的两倍。在整个正常结肠中，这两种环核苷酸的浓度相对恒定。因此，肿瘤中环核苷酸浓度异常归因于病变的特定细胞群，而非结肠内的发生部位。
