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使用冷冻同种异体移植物部分替换三尖瓣。

Partial replacement of tricuspid valve using cryopreserved homograft.

机构信息

Division of Cardiothoracic Surgery, The Prince Charles Hospital, Brisbane, Australia.

出版信息

Ann Thorac Surg. 2010 Apr;89(4):1187-94. doi: 10.1016/j.athoracsur.2009.12.047.

Abstract

BACKGROUND

The optimal choice of prosthesis for tricuspid valve (TV) replacement is yet to be determined. Partial replacement of the TV using a homograft atrioventricular valve might offer resistance to infection, good durability, and excellent functionality, in addition to avoiding prosthesis-related morbidity.

METHODS

We present 14 patients who underwent replacement of the TV using a homograft between 1997 and 2008. The mean age at operation was 32 years, including 5 patients younger than the age of 10. All patients preoperatively showed severe TV regurgitation as a result of active infective endocarditis in 5 patients, Ebstein anomaly in 4 patients, other cardiac anomalies in 4 patients, and rheumatic valvular disease in 1 patient. The TV homograft was used in 13 patients, and mitral homograft was used in 1 patient. Eleven patients had replacement of one leaflet only, whereas 3 patients required replacement of two leaflets. Concomitant cardiac procedures were performed in 7 patients.

RESULTS

No mortalities occurred during the average postoperative follow-up of 61 months (range, 12 to 126 months). Reoperation for TV regurgitation after TV repair with homograft was performed in 3 patients. The remaining 11 patients had minimal symptoms without reintervention for TV regurgitation.

CONCLUSIONS

Partial replacement of the TV using a homograft provided good hospital and mid-term outcomes. This strategy might be useful in active infective endocarditis and congenital TV disease.

摘要

背景

三尖瓣(TV)置换的最佳假体选择尚未确定。使用同种异体房室瓣进行 TV 的部分置换除了避免假体相关发病率外,还可能提供对感染的抵抗力、良好的耐久性和出色的功能。

方法

我们介绍了 1997 年至 2008 年间使用同种异体移植物置换 TV 的 14 例患者。手术时的平均年龄为 32 岁,包括 5 例年龄小于 10 岁的患者。所有患者术前均因 5 例活动性感染性心内膜炎、4 例 Ebstein 畸形、4 例其他心脏畸形和 1 例风湿性瓣膜病而出现严重的 TV 反流。13 例患者使用 TV 同种异体移植物,1 例患者使用二尖瓣同种异体移植物。11 例患者仅置换一叶,3 例患者需要置换两叶。7 例患者同时进行了心脏其他手术。

结果

在平均 61 个月(12 至 126 个月)的术后随访中,无死亡病例。3 例患者因 TV 修复后使用同种异体移植物出现 TV 反流而行再次手术。其余 11 例患者症状轻微,无需再次干预 TV 反流。

结论

使用同种异体移植物进行 TV 的部分置换提供了良好的院内和中期结果。这种策略在活动性感染性心内膜炎和先天性 TV 疾病中可能有用。

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