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经皮导管消融治疗外科消融后复发的房性心律失常。

Percutaneous catheter ablation treatment of recurring atrial arrhythmias after surgical ablation.

机构信息

Inova Heart and Vascular Institute, Falls Church, Virginia 22042, USA.

出版信息

Ann Thorac Surg. 2010 Apr;89(4):1227-31; discussion 1231-2. doi: 10.1016/j.athoracsur.2010.01.042.

Abstract

BACKGROUND

Surgical ablation for atrial fibrillation is associated with early and late recurrence of atrial arrhythmias. Although early arrhythmias may be controlled with conventional treatment, late arrhythmias are often highly symptomatic and relatively hard to manage with antiarrhythmic drugs and electrical cardioversion. This study explores a single-center experience with catheter ablation to treat late failures (>3 months) after surgery.

METHODS

This is a prospective longitudinally designed study assessing all patients who underwent surgical treatment for atrial fibrillation as a standalone or concomitant with other procedures by multiple surgeons. All patients were monitored according to the Heart Rhythm Society guidelines.

RESULTS

From January 2005 to present, 400 consecutive patients operated on by multiple surgeons were enrolled. The overall success rate per the Heart Rhythm Society guidelines was 87% and 84% (off antiarrhythmic drugs, 78% and 73%) at 12 and 24 months, respectively. Sixteen patients (4%) were referred for electrophysiology study after the surgical procedure (15 Cox-maze III or IV, 1 pulmonary vein isolation). The average age was 61.1+/-15.2 years; the mean left atrium size was 5.1+/-0.7 cm; and the mean time to ablation was 16.9+/-10 months. In 16 patients radiofrequency ablation was applied to treat the following atrial arrhythmias: 7 right atrial flutter or tachycardia, 3 left atrial flutter, 1 biatrial flutter, and 5 left atrial tachycardia. Six patients required a subsequent radiofrequency ablation intervention including 4 patients who required atrioventricular nodal ablations. The long-term success rate for the subsequent catheter ablation in these 16 patients (follow-up of 42.9+/-9.8 months) determined by the rate of sinus rhythm as captured by electrocardiography was 94%. Fifty-three percent of the patients (n=8) in sinus rhythm were still taking antiarrhythmic drugs; 8 patients remained on warfarin. There was 1 late noncardiac death and no late strokes.

CONCLUSIONS

In a certain subset of patients, unsuccessful surgical ablation of atrial fibrillation may result in symptomatic atrial arrhythmia. If indicated, catheter ablation is a safe and effective intervention with a relatively high success rate. The combination of the two treatment modalities, catheter and surgical ablation, can improve the outcome even in complex patients.

摘要

背景

房颤的外科消融术与房颤的早期和晚期复发有关。尽管早期心律失常可以通过常规治疗来控制,但晚期心律失常往往具有高度的症状性,并且相对难以用抗心律失常药物和电复律来管理。本研究探讨了单中心经导管消融治疗术后 3 个月以上(晚期)失败的经验。

方法

这是一项前瞻性纵向设计的研究,评估了由多位外科医生为孤立性房颤或合并其他手术而进行手术治疗的所有患者。所有患者均根据心律协会指南进行监测。

结果

从 2005 年 1 月至今,共有 400 名连续患者被纳入研究。根据心律协会指南,总体成功率为 87%和 84%(停用抗心律失常药物时为 78%和 73%),分别在 12 个月和 24 个月时。手术后有 16 名患者(4%)被转介进行电生理研究(15 例 Cox 迷宫 III 或 IV,1 例肺静脉隔离)。平均年龄为 61.1+/-15.2 岁;平均左心房大小为 5.1+/-0.7cm;消融平均时间为 16.9+/-10 个月。在 16 名患者中,采用射频消融治疗以下房性心律失常:7 例右侧房性心动过速或房扑、3 例左侧房性心动过速、1 例双心房房扑和 5 例左侧房性心动过速。6 名患者需要进行后续射频消融介入治疗,其中 4 名患者需要房室结消融。这 16 名患者(随访 42.9+/-9.8 个月)的后续导管消融的长期成功率(心电图记录的窦性心律率)为 94%。53%(n=8)的窦性心律患者仍在服用抗心律失常药物;8 名患者仍在服用华法林。有 1 例晚期非心源性死亡,无晚期中风。

结论

在某些特定患者中,房颤的外科消融术不成功可能导致有症状的房性心律失常。如果需要,导管消融是一种安全有效的治疗方法,成功率相对较高。导管和外科消融两种治疗方法的结合甚至可以改善复杂患者的预后。

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