Department of Oral Surgery, Jagiellonian University Medical College, Krakow, Poland.
Int J Oral Maxillofac Surg. 2010 Jul;39(7):647-52. doi: 10.1016/j.ijom.2010.02.019. Epub 2010 Mar 24.
The authors examined whether ketoprofen administered 60 min before surgical extraction of the lower wisdom teeth provides effective postsurgical analgesia and reduces rescue analgesic intake compared with ketoprofen administered 60 min after surgery or placebo. The 96 patients were placed into three groups: pre-group (ketoprofen 60 min preoperatively); post-group (ketoprofen 60 min postoperatively); and no-group (placebo). Study interventions had a significant effect on pain sensations in the 12 h after surgery. The initial onset of pain was significantly delayed only in the post-group. Pain intensity at the first onset of pain was significantly lower only in the post-group. Patients in the pre- and post-groups required significantly less rescue analgesic than those in the no-group. Ketoprofen administered after third molar surgery provides more effective pain control than ketoprofen administered before the surgery or placebo.
作者研究了在接受下颌智齿拔除术之前 60 分钟给予酮咯酸与术后 60 分钟给予酮咯酸或安慰剂相比，是否能提供有效的术后镇痛并减少解救性镇痛药物的摄入。96 名患者被分为三组：术前组（术前 60 分钟给予酮咯酸）；术后组（术后 60 分钟给予酮咯酸）；无治疗组（安慰剂）。研究干预措施对术后 12 小时的疼痛感觉有显著影响。仅在术后组，疼痛的初始发作明显延迟。仅在术后组，首次发作时的疼痛强度明显降低。与无治疗组相比，术前组和术后组患者需要的解救性镇痛药物明显更少。与手术前给药或安慰剂相比，第三磨牙手术后给予酮咯酸能更有效地控制疼痛。
