Harvard School of Public Health, 665 Huntington Avenue, Building 1-1407, Boston, MA 02115, USA.
Am J Respir Crit Care Med. 2010 Jul 15;182(2):200-6. doi: 10.1164/rccm.200903-0329OC. Epub 2010 Mar 25.
The degree to which chronic respiratory health effects caused by exposures to cotton dust and endotoxin is reversible after cessation of textile work is unknown.
To investigate changes in lung function and respiratory symptoms after cessation of textile work and to determine whether past exposure to cotton dust and endotoxin or smoking history modify the associations.
We performed a prospective cohort study consisting of 447 cotton textile workers exposed to cotton dust and 472 unexposed silk textile workers, with a 25-year follow-up. Spirometry testing and respiratory questionnaires were conducted at 5-year intervals. Generalized estimated equations were used to model the average 5-year change in FEV(1) and odds ratios of respiratory symptom prevalence.
Years since cessation of textile work was positively associated with 11.3 ml/yr and 5.6 ml/yr gains in 5-year FEV(1) change for cotton and silk workers, respectively. Among male cotton workers, smokers gained more FEV(1) per year after cessation of exposure than did nonsmokers, and the risk of symptoms of chronic bronchitis and byssinosis was larger for smoking than for nonsmoking male cotton workers.
Cessation of textile work was significantly associated with improvement in lung function and respiratory symptoms. The positive effect of work cessation was greater for cotton workers than for silk workers. For cotton workers, the improvement in lung function loss after cessation of textile work was greater among smokers, but no differences were observed for silk workers.
暴露于棉尘和内毒素引起的慢性呼吸道健康影响在停止纺织工作后能在多大程度上恢复尚不清楚。
调查停止纺织工作后肺功能和呼吸道症状的变化，并确定过去暴露于棉尘和内毒素或吸烟史是否改变了这些关联。
我们进行了一项前瞻性队列研究，纳入了 447 名接触棉尘的棉纺织工人和 472 名未接触棉尘的丝纺织工人，随访 25 年。每隔 5 年进行一次肺功能测试和呼吸问卷。采用广义估计方程来模拟 FEV1 的平均 5 年变化和呼吸道症状发生率的比值比。
停止纺织工作的年限与棉纺织和丝纺织工人的 5 年 FEV1 变化分别呈正相关，每年分别增加 11.3 ml 和 5.6 ml。在男性棉纺织工人中，与不吸烟者相比，停止暴露后吸烟者每年的 FEV1 增加更多，且与不吸烟者相比，吸烟的男性棉纺织工人患慢性支气管炎和棉尘肺的风险更大。
停止纺织工作与肺功能和呼吸道症状的改善显著相关。停止纺织工作对棉纺织工人的影响大于丝纺织工人。对于棉纺织工人，停止纺织工作后肺功能损失的改善在吸烟者中更大，但在丝纺织工人中未观察到差异。
