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分析人脑膜瘤中的几种 PLA2mRNA。

Analysis of several PLA2 mRNA in human meningiomas.

机构信息

UMR CNRS 6101, Centre National de la Recherche Scientifique, Faculté de Médecine, Université de Limoges, Limoges, France.

出版信息

Mediators Inflamm. 2009;2009:689430. doi: 10.1155/2009/689430. Epub 2010 Mar 21.

DOI:10.1155/2009/689430
PMID:20339511
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2842896/
Abstract

In view of the important oncogenic action of phospholipase A(2)(PLA(2)) we investigated PLA(2) transcripts in human meningiomas. Real-time PCR was used to investigate PLA(2) transcripts in 26 human meningioma tumors. Results indicated that three Ca(2+)-dependent high molecular weight PLA(2) (PLA(2)-IVA, PLA(2)-IVB, PLA(2)-IVC), one Ca(2+)-independent high molecular weight PLA(2) (PLA(2)-VI) and five low molecular weight secreted forms of PLA(2) (PLA(2)-IB, PLA(2)-IIA, PLA(2)-III, PLA(2)-V, and PLA(2)-XII) are expressed with PLA(2)-IVA, PLA(2)-IVB, PLA(2)-VI, and PLA(2)-XIIA as the major expressed forms. PLA(2)-IIE, PLA(2)-IIF, PLA(2)-IVD, and PLA(2)-XIIB are not detected. Plasma (PLA(2)-VIIA) and intracellular (PLA(2)-VIIB) platelet-activating factor acetylhydrolase transcripts are expressed in human meningiomas. However no difference was found for PLA(2) transcript amounts in relation to the tumor grade, the subtype of meningiomas, the presence of inflammatory infiltrated cells, of an associated edema, mitosis, brain invasion, vascularisation or necrosis. In conclusion numerous genes encoding multiples forms of PLA(2) are expressed in meningiomas where they might act on the phospholipid remodeling and on the local eicosanoid and/or cytokine networks.

摘要

鉴于磷脂酶 A(2)(PLA(2))具有重要的致癌作用，我们研究了人脑膜瘤中的 PLA(2)转录本。使用实时 PCR 研究了 26 个人脑膜瘤肿瘤中的 PLA(2)转录本。结果表明，三种 Ca(2+)依赖性高分子量 PLA(2)(PLA(2)-IVA、PLA(2)-IVB、PLA(2)-IVC)、一种 Ca(2+)非依赖性高分子量 PLA(2)(PLA(2)-VI)和五种低分子量分泌型 PLA(2)(PLA(2)-IB、PLA(2)-IIA、PLA(2)-III、PLA(2)-V 和 PLA(2)-XII)表达，以 PLA(2)-IVA、PLA(2)-IVB、PLA(2)-VI 和 PLA(2)-XIIA 为主要表达形式。未检测到 PLA(2)-IIE、PLA(2)-IIF、PLA(2)-IVD 和 PLA(2)-XIIB。人脑膜瘤中表达血浆 (PLA(2)-VIIA)和细胞内 (PLA(2)-VIIB)血小板激活因子乙酰水解酶转录本。然而，PLA(2)转录本的量与肿瘤分级、脑膜瘤亚型、炎症浸润细胞的存在、相关水肿、有丝分裂、脑侵犯、血管生成或坏死无关。总之，许多编码多种形式 PLA(2)的基因在脑膜瘤中表达，它们可能作用于磷脂重塑和局部类花生酸和/或细胞因子网络。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4270/2842896/5979a413254b/MI2009-689430.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4270/2842896/d27762433c6d/MI2009-689430.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4270/2842896/09267361e007/MI2009-689430.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4270/2842896/65a6971e1d05/MI2009-689430.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4270/2842896/5979a413254b/MI2009-689430.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4270/2842896/d27762433c6d/MI2009-689430.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4270/2842896/09267361e007/MI2009-689430.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4270/2842896/65a6971e1d05/MI2009-689430.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4270/2842896/5979a413254b/MI2009-689430.004.jpg

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