Da Costa B, Djilali S, Kessler J L, Sacré B, Femenia F, Parodi A L
Laboratoire d'Anatomie Pathologique-INRA, Ecole Nationale Vétérinaire, Alfort, France.
Leukemia. 1991 May;5(5):420-4.
A total of 216 cases of the thymic form of bovine leukosis were observed in Holstein calves in several departments of France over a period of 18 months. Almost all of these calves were sired by the same bull. The calves were negative for bovine leukemia virus-specific antibodies. Morphological studies, including light and electron microscopic cytology, and immunophenotyping were performed in 38 cases. The tumor cells exhibit membrane markers (T-cell antigens) at variable levels, which indicate that they are T-lymphoid derived. The cells are maintained at a very early stage of differentiation as indicated by TdT enzyme activity and the presence of MHC class II antigen.
在18个月的时间里，法国几个部门对荷斯坦小牛的胸腺型牛白血病进行了观察，共观察到216例。几乎所有这些小牛都是同一头公牛的后代。这些小牛的牛白血病病毒特异性抗体呈阴性。对其中38例进行了形态学研究，包括光镜和电镜细胞学检查以及免疫表型分析。肿瘤细胞呈现出不同水平的膜标记物（T细胞抗原），这表明它们来源于T淋巴细胞。TdT酶活性和MHC II类抗原的存在表明这些细胞处于非常早期的分化阶段。
