National Science and Technology Institute (INCT) for Translational Medicine, Brazil.
Braz J Psychiatry. 2010 Mar;32(1):83-90. doi: 10.1590/s1516-44462010000100016.
Translational medicine has been described as the integrated application of innovative pharmacology tools, biomarkers, clinical methods, clinical technologies and study designs to improve the understanding of medical disorders. In medicine, translational research offers an opportunity for applying the findings obtained from basic research to every-day clinical applications. The National Science and Technology Institute for Translational Medicine is comprised of six member institutions (Universidade Federal do Rio Grande do Sul, Universidade de São Paulo-Ribeirão Preto, Universidade Federal do Rio de Janeiro, Pontifícia Universidade Católica do Rio Grande do Sul, Universidade Estadual de Santa Catarina and a core facility that serves all centers). The objectives of the project are divided into four areas: Institutional, Research, Human Resources and Technology for the Community and Productive Sector.
In this manuscript, we describe some of the approaches used to attain the main objectives of the National Science and Technology Institute for Translational Medicine, which include the development of 1) animal models for bipolar disorder; 2) strategies to investigate neurobehavioral function and cognitive dysfunction associated with brain disorders; 3) experimental models of brain function and behavior, neuropsychiatric disorders, cell proliferation, and cancer; 4) Simulated Public Speaking and 5) Virtual reality simulation for inducing panic disorder and agoraphobia.
The main focus of the National Science and Technology Institute for Translational Medicine is the development of more useful methods that allow for a better application of basic research-based knowledge to the medical field.
转化医学被描述为创新的药理学工具、生物标志物、临床方法、临床技术和研究设计的综合应用，以提高对医学疾病的认识。在医学中，转化研究为将基础研究中获得的发现应用于日常临床应用提供了机会。国家转化医学科学技术研究所由六个成员机构（南里奥格兰德州联邦大学、里贝朗普雷图圣保罗大学、里约热内卢联邦大学、南里奥格兰德州天主教大学、圣卡塔琳娜州立大学和一个为所有中心服务的核心设施）组成。该项目的目标分为四个领域：机构、研究、人力资源和社区及生产部门的技术。
在本文中，我们描述了实现国家转化医学科学技术研究所主要目标的一些方法，包括开发 1）双相情感障碍的动物模型；2）研究与脑疾病相关的神经行为功能和认知功能障碍的策略；3）脑功能和行为、神经精神障碍、细胞增殖和癌症的实验模型；4）模拟公开演讲；5）用于诱发恐慌症和广场恐惧症的虚拟现实模拟。
国家转化医学科学技术研究所的主要重点是开发更有用的方法，以便更好地将基于基础研究的知识应用于医学领域。
